1. Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey
- Author
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Gulen Guler, Ahmet Buber, Ozgur Kutuk, Nurdan Coban, Ufuk Acikbas, Fatma Celik, Tuba Mutluer, Aslı Giray, Hasan Kandemir, Fethiye Kilicaslan, Yeliz Aka, Cem Gokcen, Zehra Topal, Seyma Coskun, Mehmet Karadag, Meryem Ozlem Kutuk, Evren Tufan, Çiğdem Yektaş, Ebru Altintas, ALKÜ, 0-belirlenecek, and [Belirlenecek]
- Subjects
0301 basic medicine ,Pediatrics ,interleukin 1beta ,Turkey ,peripheral blood mononuclear cell ,Autism Spectrum Disorder ,clinical evaluation ,Interleukin-1beta ,Biochemistry ,Turkey (republic) ,0302 clinical medicine ,Neurodevelopmental disorder ,Childhood Autism Rating Scale ,Receptors ,cytokine ,Immunology and Allergy ,Children ,Cells, Cultured ,developmental disorder ,transforming growth factor beta ,child ,messenger RNA ,Hematology ,symptom ,comorbidity ,female ,priority journal ,Autism spectrum disorder ,030220 oncology & carcinogenesis ,Cytokines ,disease severity ,Cns ,Autistic symptoms ,Adult ,Risk ,medicine.medical_specialty ,tumor necrosis factor ,Immunology ,attention deficit disorder ,interleukin 6 ,autism ,behavioral disciplines and activities ,interleukin 4 ,Article ,03 medical and health sciences ,male ,mental disorders ,medicine ,Humans ,controlled study ,human ,Autistic Disorder ,Molecular Biology ,protein expression ,Autoantibodies ,Inflammation ,Autoimmune-Diseases ,business.industry ,intellectual developmental disorder ,Immunity ,Cytokine expression ,medicine.disease ,major clinical study ,clinical feature ,Developmental disorder ,immune system ,Aberrations ,030104 developmental biology ,Immune system ,multicenter study ,Multi center study ,adolescent ,Leukocytes, Mononuclear ,Etiology ,interleukin 1alpha ,gene expression ,Interleukin-4 ,business ,interleukin 17 - Abstract
Topal, Zehra/0000-0001-8397-5636; Kandemir, Hasan/0000-0002-1138-4973; Tufan, Evren/0000-0001-5207-6240; KUTUK, OZGUR/0000-0001-9854-7220 WOS: 000554002300029 PubMed: 32563959 Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has demonstrated that the immune response may be a contributing factor in the etiology and/or ontogeny of ASD. The aim of this study was to determine the expression levels of IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-beta in peripheral blood mononuclear cells of children with ASD and healthy controls in order to determine the contributions of cytokines to ASD. Within the study timeframe, 195 children with ASDs (80.5% male) and 162 controls (73.6% male) were enrolled. Most children with ASD had a comorbid disorder (n = 114, 58.5%), with the most common diagnoses as Intellectual Developmental Disorder (IDD, n = 64, 32.8%) and ADHD (n = 64, 32.8%). The majority of children with ASD had severe autistic symptoms as evaluated via Childhood Autism Rating Scale (CARS, n = 130, 64.6%). The mean CARS score in the ASD sample was 40.8 (S.D. = 7.6). The patients with ASD were found to have significantly higher levels of IL-6 (p < 0.001) and significantly lower levels of IL-17 (p < 0.05, all Bonferroni corrected). Treatment tended to affect IL-4 levels. Lastly, discriminant function analysis (DFA) revealed that a combination of IL-6, IL-17 and IL-1 alpha correctly classified 56.6% of cases. Despite extensive immunological evidence suggesting immune system aberrations, further research is required to clarify the relationship between immune profiles and ASD symptoms. Science Academy BAGEP program Ozgur Kutuk acknowledges support from Science Academy BAGEP program.
- Published
- 2020