1. A systems approach to understanding human rhinovirus and influenza virus infection.
- Author
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Kim TK, Bheda-Malge A, Lin Y, Sreekrishna K, Adams R, Robinson MK, Bascom CC, Tiesman JP, Isfort RJ, and Gelinas R
- Subjects
- Apoptosis, Bronchi cytology, Bronchi immunology, Bronchi virology, Epithelial Cells cytology, Epithelial Cells virology, Humans, Influenza, Human genetics, Influenza, Human immunology, Influenza, Human physiopathology, Picornaviridae Infections genetics, Picornaviridae Infections immunology, Picornaviridae Infections physiopathology, Influenza A Virus, H1N1 Subtype physiology, Influenza, Human virology, Picornaviridae Infections virology, Rhinovirus physiology
- Abstract
Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influenza virus or co-infection with both viruses, we studied the time-course of host gene expression changes over three days. We modeled host responses to these viral infections with time and documented the qualitative and quantitative differences in innate immune activation and regulation., (Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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