1. Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma.
- Author
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Chaturvedi VK, Singh A, Dubey SK, Hetta HF, John J, and Singh MP
- Subjects
- Angiogenesis Inhibitors pharmacology, Antiviral Agents pharmacology, Apoptosis, Biomarkers blood, Biomarkers urine, Carcinoma, Hepatocellular epidemiology, Carcinoma, Hepatocellular immunology, Carcinoma, Hepatocellular pathology, Cell Proliferation, Drug Delivery Systems, ErbB Receptors drug effects, Hepatitis B complications, Hepatitis B virology, Hepatitis B Surface Antigens physiology, Hepatitis B virus drug effects, Hepatitis B virus growth & development, Hepatocytes pathology, Hepatocytes virology, Humans, Inflammation, Life Cycle Stages, Liver, Liver Cirrhosis pathology, Liver Neoplasms epidemiology, Liver Neoplasms immunology, Liver Neoplasms pathology, MicroRNAs metabolism, Mutation, Nucleocapsid metabolism, Oncogene Proteins, Viral metabolism, Pathology, Molecular, Risk Factors, Signal Transduction, Trans-Activators metabolism, Viral Load, Viral Regulatory and Accessory Proteins, Carcinoma, Hepatocellular virology, Hepatitis B virus genetics, Hepatitis B virus pathogenicity, Liver Neoplasms virology
- Abstract
Hepatocellular carcinoma (HCC) is a cancer which occurs in liver and severity of this cancer makes it the sixth most prevalent cancer and second leading cause of death among all cancers. The load of hepatitis-B virus (HBV) in serum is one of the important risk factors for the HCC. Several other factors also contribute to the HBV associated malignant hepatoma (HCC) i.e. HBV mutation, integration and condition of the host. Transformation of the liver to HBV-associated HCC usually accompanies long-run symptoms i.e. inflammation and cirrhosis of the liver and infective agent load could be a vigorous prognosticator for each incidence and progression of this carcinoma. One of the prominent factors i.e. HBV X supermolecule (HBx) interferes with many signal pathways that are related to the proliferation and apoptosis of hepatic cells. Besides, HBx C-terminal truncation is also responsible for HCC. Longtime HBV infection causes risk of HCC; thus most of the study related to HBV (85%) is limited to HBV endemic regions. In this review, we have outlined the molecular mechanisms that come from other than HBV endemic places which can be innovative approaches to treat HCC., (Copyright © 2019. Published by Elsevier Ltd.)
- Published
- 2019
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