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Sodium percarbonate (SPC) is considered a potential alternative to liquid hydrogen peroxide (H 2 O 2) in organic compounds contaminated water/soil remediation due to its regularly, transportable, economical, and eco-friendly features. The solid state of SPC makes it more suitable to remediate actual soil and water with a milder H 2 O 2 release rate. Apart from its good oxidative capacity, alkaline SPC can simultaneously remediate acidized solution and soil to the neutral condition. Conventionally, percarbonate-based advanced oxidation process (P-AOPs) system proceed through the catalysis under ultraviolet ray, transition metal ions (i.e. , Fe2+, Fe3+, and V4+), and nanoscale zero-valent metals (iron, zinc, copper, and nickel). The hydroxyl radical (•OH), superoxide radical (•O 2 −), and carbonate radical anion (•CO 3 −) generated from sodium percarbonate could attack the organic pollutant structure. In this review, we present the advances of P-AOPs in heterogeneous and homogeneous catalytic processes through a wide range of activation methods. This review aims to give an overview of the catalysis and application of P-AOPs for emerging contaminants degradation and act as a guideline of the field advances. Various activation methods of percarbonate are summarized, and the influence factors in the solution matrix such as pH, anions, and cations are thoroughly discussed. Moreover, this review helps to clarify the advantages and shortcomings of P-AOPs in current scientific progress and guide the future practical direction of P-AOPs in sustainable carbon catalysis and green chemistry. [Display omitted] • Multifaceted comparisons with typical advanced oxidant process have been done. • Activations of percarbonate for containment destruction are summarized. • The influence factors of organic compounds oxidation by percarbonate are presented. • P-AOPs may be economically feasible for organic matter reduction in the future. • Future prospect and challenges of percarbonate application are proposed. [ABSTRACT FROM AUTHOR]

Activation of the NLRP3 inflammasome plays an important role in high glucose- induced endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM). Dulaglutide, a newly developed glucagon-like peptide-1 receptor (GLP-1R) agonist, has been approved for the management of T2DM. In the current study, we aimed to investigate whether dulaglutide possesses a protective effect against high glucose- induced activation of the NLRP3 inflammasome. Our results indicate that dulaglutide treatment prevented high glucose- induced generation of reactive oxygen species (ROS) and protein carbonyl, as well as the expression of NADPH oxidase 4 (NOX-4) in human umbilical vein endothelial cells (HUVECs). Dulaglutide treatment could inhibit high glucose- induced release of lactate dehydrogenase (LDH) and the expression of TXNIP. Dulaglutide suppressed high glucose- induced activation of NLRP3 inflammasome by reducing the expression of NLRP3, ASC, and cleaved caspase 1 (P10). Notably, dulaglutide treatment suppressed high glucose- induced maturation of IL-1β and IL-18. Mechanistically, our findings indicate that SIRT1 was involved in this process by showing that knockdown of SIRT1 by transfection with SIRT1 siRNA abolished the inhibitory effects of dulaglutide on IL-1β and IL-18 secretion via suppression of NLRP3, ASC, and p10. These data suggest that dulaglutide might serve as a potential drug for the treatment of cardiovascular complications in T2DM patients. [ABSTRACT FROM AUTHOR]