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The binding of calmodulin (CaM) to NMDAR (N-methyl-D-aspartate receptor) GluN1 C-terminus is required for cacium (Ca2+)/calmodulin (CaM)-dependent inactivation of NMDAR. Previously, we found that GluN1 C-terminus translocated to nucleus, and regulated synaptic transmission. However, whether GluN1 C-terminus containing the nuclear localization signaling regulates the cellular distribution of CaM, and the CaM binding are not clear. In this study, we found that the 10 positive residues of GluN1 C-terminus determined the translocation of CaM to the nucleus. RNA sequencing data showed that CaM could regulate the genes expression of multiple cell surface membrane receptors. This was confirmed by electrophysiology data that the 10A mutation of GluN1 C-terminus increased the NMDAR/AMAPR-mediated synaptic transduction. Image 1 • GluN1-1a-ct shuttles CaM to the cellular nucleus. • CaM regulates multiple genes expression. • The GluN1 C-terminal mutant potentiates NMDAR/AMPAR-mediated synaptic transduction. [ABSTRACT FROM AUTHOR]

Two chiral coordination polymers [CuI(TMBP)(CH 3 CN) 2 ·ClO 4 ] n (1) and [ZnII(TMBP)(SCN) 2 ] n (2) have been synthesized with 3,3',5,5'-tetramethyl-4,4'-bipyrazole (TMBP) as ligand. Their structures were determined by single-crystal X-ray diffraction (SCXRD) analysis and further characterized by power X-ray diffraction (PXRD) analysis, FT-IR spectroscopy, and thermogravimetric (TG) analysis. 1 is constructed by left-handed double-stranded helices with the same chirality, while 2 possesses right-handed single-helical chains. The existence of ClO 4 − in 1 might be the main reason for forming double-stranded helices, while it leads to single-helical chains under induction of SCN−, exhibiting a anion-directed synthesis process. The selected two single crystals are both homochiral according to the Flack parameters (≈0) from crystal refinement. The bulk sample of 1 exhibits a negative solid-state Cotton effect, while that of 2 shows a positive one. In addition, the crystal sample of 1 exhibits strong ligand-based and metal to ligand charge transition (MLCT) emission in solid-state luminescence with comparison to weakly luminous 2 at room temperature. Two kinds of homochiral crystals of coordination polymers were achieved from anions-induced solvothermal method, and their spectral properties were investigated and compared. Image 1 • Two kinds of homochiral crystals were prepared and determined by SCXRD. • ClO 4 −-directed 1 possesses double-stranded helices while SCN−-induced 2 possesses single-helical chains. • Bulk sample of 1 exhibits MLCT emission with comparison to weakly luminous 2. [ABSTRACT FROM AUTHOR]