1. Deciphering the toxic effects of antibiotics on denitrification: Process performance, microbial community and antibiotic resistance genes.
- Author
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Fan, Nian-Si, Bai, Yu-Hui, Chen, Qian-Qian, Shen, Yang-Yang, Huang, Bao-Cheng, and Jin, Ren-Cun
- Subjects
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DRUG resistance in bacteria , *ANTIBIOTICS , *DENITRIFICATION , *MICROBIAL communities , *TETRACYCLINES , *GENES - Abstract
The extensive application of antibiotics, and the occurrence and spread of antibiotic resistance genes (ARGs) shade health risks to human and animal. The long-term effects of sulfamethoxazole (SMX) and tetracycline (TC) on denitrification process were evaluated in this study, with the focus on nitrogen removal performance, microbial community and ARGs. Results showed that low-concentration SMX and TC (<0.2 mg L−1) initially caused a deterioration in nitrogen removal performance, while higher concentrations (0.4–20 mg L−1) of both antibiotics had no further inhibitory influences. The abundances of ARGs in both systems generally increased during the whole period, and most of them had significant correlations with int I1, especially efflux-pump genes. Castellaniella , which was the dominant genus under antibiotic pressure, might be potential resistant bacteria. These findings provide an insight into the toxic effects of different antibiotics on denitrification process, and guides future efforts to control antibiotics pollution in ecosystems. • Denitrification performance deteriorated at low concentrations of antibiotics. • The antibiotic inhibition on denitrification was reversible. • Castellaniella was mainly devoted to denitrification under antibiotics pressures. • Antibiotics addition promoted the increase in antibiotic resistance genes (ARGs). • Most ARGs were significantly correlated to int I1, especially efflux-pump ARGs. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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