1. Regulation of CD8+ T cell functions by RARγ
- Author
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Gordy, Claire, Dzhagalov, Ivan, and He, You-Wen
- Subjects
- *
CELL physiology , *T cells , *TRETINOIN , *IMMUNE response , *CELL receptors , *RETINAL (Visual pigment) , *DEHYDROGENASES - Abstract
Abstract: Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARα and RARγ are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARα and RARγ function differently in thymocyte development and that RARγ is required for both primary and secondary CD8+ T cell immune responses. [Copyright &y& Elsevier]
- Published
- 2009
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