Search

Ralstonia solanacearum a phytopathogenic bacterium produces virulence factor via production of extracellular polysaccharides (EPS). We have isolated EPS from R. solanacearum and characterized this by AFM, SEM, FTIR, LC-MS and NMR spectroscopy. Interestingly, the result showed pore size distribution, topology, rheological and pseudoplastic behaviour of EPS and three major monosaccharides, glucuronic acid, N -acetylglucosamine and glucose associated with EPS. Eggplant treated with intact crude EPS showed a significant 51% decrease in bacterial wilt incidence for both in vitro and greenhouse conditions. In eggplant cultivars EPS induces significant up-regulation of guaiacol peroxidase and ascorbate peroxidase defense genes, providing screen resistance against bacterial wilt. [ABSTRACT FROM AUTHOR]

[Display omitted] • The sulfur (VI) fluoride exchange (SuFEx), is one among the most important click chemistry transformations. • Detailed explanation of structure–activity relationships (SAR) of SO 2 F compounds. • SF-based activity probes have become an attractive tool in chemical biology. • We have discussed application of SuFEx click chemistry in drug discovery and chemical biology. Compounds containing an S F bond have garnered intense interest in the chemical and biological literature. In particular, sulfonyl fluorides (RSO 2 F) are commonly used as covalent protein inhibitors and biological probes. The introduction of the fluorine atom into drugs often leads to significantly promoted medicinal properties, which revolutionized the development of pharmaceuticals and gained attention because of the beneficial properties of these small and highly electro-negative halogens. The sulfonyl fluoride functional group has also been widely adopted throughout the field of chemical biology due to its unique balance between reactivity and stability under physiological conditions. This comprehensive review highlights the recent developments of sulfonyl fluorides based compounds in a massive range of therapeutic applications. We believe this review article will be helpful to inspire new ideas for structural design and developments of less toxic and potent Sulfur based drugs against the numerous death-causing diseases. [ABSTRACT FROM AUTHOR]