1. Genome analysis of the mpox (formerly monkeypox) virus and characterization of core/variable regions.
- Author
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Yu, Zehui, Zou, Xiaoxia, Deng, Zhaobin, Zhao, Mingde, Gu, Congwei, Fu, Lu, Xiao, Wudian, He, Manli, He, Lvqin, Yang, Qian, Liang, Sicheng, Wen, Chengli, and Lü, Muhan
- Subjects
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MONKEYPOX , *WHOLE genome sequencing , *SINGLE nucleotide polymorphisms - Abstract
Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as the most threatening orthopoxvirus in the world. In this study, we conducted a comprehensive analysis of the currently published complete genome sequences of the monkeypox virus. The core/variable regions were identified through core-pan analysis of MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy genes, repeat sequences, and recombination fragments are primarily distributed in the variable region. This result suggests that variable regions are not only more susceptible to single-base mutations, but also to events such as gene loss or gain, as well as recombination. Taken together, our results demonstrate the genomic characteristics of the core/variable regions of MPXV, and contribute to our understanding of the evolution of MPXV. • Our study found that specific genes, multi-copy genes, repeat sequences and recombination fragments are mostly distributed in the variable region. • Our results demonstrate genomic characteristics of core/variable regions of the mpxv. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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