1. Autophagy in vascular dementia and natural products with autophagy regulating activity.
- Author
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Wang, Wenzhe, Qiao, Ou, Ji, Haixia, Zhang, Xinyu, Han, Xiaoying, Zhang, Yi, Wang, Juan, Li, Xia, and Gao, Wenyuan
- Subjects
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VASCULAR dementia , *AUTOPHAGY , *NATURAL products , *COGNITIVE ability , *CENTRAL nervous system - Abstract
Chronic Cerebral Hypoperfusion(CCH)-induced vascular dementia(VD) is a common neurodegenerative disease which seriously affects the patient's quality of life. Therefore, it is critical to find an effective treatment of VD. Autophagy is a natural regulated mechanism that can remove dysfunctional proteins and organelles, however, over-activation or under-activation can of autophagy can induce the apoptosis of cells. Although autophagy plays a role in the central nervous system is unquestionable, the effects of autophagy in the ischemic brain are still controversial. Some autophagy regulators have been tested, suggesting that both activation and inhibition of autophagy can improve the cognitive function. This article reviews the role of autophagy in CCH-induced VD to discuss whether autophagy has the potential to become a target for drug development and provides several potential compounds for treating vascular dementia. [Display omitted] • Autophagy is activated in chronic hypoperfusion-induced vascular dementia. • Mild to moderate autophagy activation is beneficial for the recovery of vascular dementia. • Excessive activation of autophagy can cause apoptosis. • Targeted autophagy therapy may be a new direction for the treatment of vascular dementia. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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