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[Display omitted] In recent years, antibody-drug conjugate (ADC) technology, which uses monoclonal antibodies (mAbs) to specifically deliver effective cytotoxic payloads to tumor cells, has become a promising method of tumor targeted therapy. ADCs are a powerful class of biopharmaceuticals that link antibodies targeting specific antigens and small molecule drugs with potent cytotoxicity via a linker, thus enabling selective destruction of cancer cells while minimizing systemic toxicity. DXd is a topoisomerase I inhibitor that induces DNA damage leading to cell cycle arrest, making it an option for ADC payloads. The DXd-ADC technology, developed by Daiichi Sankyo, is a cutting-edge platform that produces a new generation of ADCs with improved therapeutic metrics and has shown significant therapeutic potential in various types of cancer. This review provides a comprehensive assessment of drugs developed with DXd-ADC technology, with a focus on mechanisms of action, pharmacokinetics studies, preclinical data, and clinical outcomes for DS-8201a, U3-1402, DS-1062a, DS-7300a, DS-6157a, and DS-6000a. By integrating existing data, we aim to provide valuable insights into the current therapeutic status and future prospects of these novel agents. [ABSTRACT FROM AUTHOR]

• The out-of-plane resonant stiffness difference is introduced to break the space inversion symmetry. • The nontrivial nature of the discrete spring-mass lattice model is verified via both theoretical and numerical investigation. • This symmetry-breaking configuration can be extended to the continuum plate-resonator model successively. • The programmable topological interface path is realized by using the asymmetric effective stiffness of the bistable structure between tension and compression. Topological metamaterials provide a new strategy to guide wave energy and exhibit unprecedented robustness. In this study, a novel design strategy is proposed to realize programmable topological metamaterials with local resonant eigenstates. Firstly, in the discrete spring-mass model, two resonant masses and two base masses are introduced into the hexagonal lattice, and a local resonant eigenstate-induced Dirac cone can be formed at the high symmetry point of the Brillouin zone. By introducing the spring stiffness difference, a topological bandgap is opened near the Dirac degeneracy frequency. Thereafter, the nontrivial nature of the bandgap is verified by the theoretical evaluation of the Berry curvature and Chern number. Secondly, the symmetry-breaking configuration is extended to a continuum plate-resonator model. The numerical results demonstrate that the interface state wave propagates along the interface path at a frequency located at the edge-bulk band. Finally, by using the asymmetric effective stiffness of the bistable structure between tension and compression, a programmable topological interface path is realized. The proposed reconfigurable design based on asymmetry significantly expands the design space of metamaterials. [ABSTRACT FROM AUTHOR]