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Doxorubicin, as a first line chemotherapeutic agent, its usage is limited owing to cardiotoxicity. Necroptosis is a new form of programmed cell death, and recent investigations indicated that necroptosis is vitally involved in serious cardiac pathological conditions. Dexrazoxane is the only cardiac protective drug approved by FDA for anthracycline. We aimed to explore whether and how dexrazoxane regulates doxorubicin-induced cardiomyocyte necroptosis. First, doxorubicin could cause heart failure and reduce cardiomyocyte viability by promoting cell apoptosis and necroptosis in vivo and in vitro. Second, necroptosis plays an important role in doxorubicin induced cardiomyocyte injury, which could be inhibited by Nec-1. Third, dexrazoxane increased cell viability and protect heart function by decreasing both cardiomyocyte apoptosis and necroptosis after doxorubicin treatment. Forth, dexrazoxane attenuated doxorubicin-induced inflammation and necroptosis by the inhibition of p38MAPK/NF-κB pathways. These results indicated that dexrazoxane ameliorates cardiotoxicity and protects heart function by attenuating both apoptosis and necroptosis in doxorubicin induced cardiomyocyte injury. • Doxorubicin causes both apoptosis and necroptosis in cardiomyocyte. • Dexrazoxane attenuates doxorubicin-induced cardiomyocyte necroptosis and apoptosis. • Dexrazoxane alleviates cardiotoxicity by inhibition of p38MAPK/NF-κB pathway. [ABSTRACT FROM AUTHOR]

Graphical abstract Abstract Aluminum hydroxide and oxide have been widely used for decontamination due to their environmentally friendly nature and cost effectiveness. Aluminum (hydro) oxides are the main phases of aluminum-derived environment materials. Herein, the solvent-free hydrothermal synthesis of gamma-aluminum oxide (γ-Al 2 O 3) nanoparticles and phase transformation of AlOOH into γ-Al 2 O 3 are reported. Hydrothermal treatment of NH 3 ·H 2 O-induced aluminum precipitate resulted in the formation of AlOOH, which was an intermediate product of γ-Al 2 O 3. AlOOH was transformed into highly crystalline 20-nm γ-Al 2 O 3 particles through calcination at 500 °C due to dehydration. The transformation was confirmed through X-ray diffraction (XRD) and thermogravimetric (TG) analyses. The resulting γ-Al 2 O 3 had superior adsorption ability for the anionic Congo red (CR) dye than for the cationic methylene blue (MB) and malachite green (MG) dyes. The selective adsorption ability of CR instead of MB was attributed to the electrostatic attraction and hydrogen bonds between the amino group and azo double bond of CR, and between the amino group and hydroxyl group in γ-Al 2 O 3. Thus, this study investigated crystalline phase transformation into γ-Al 2 O 3 and selective adsorption capacity of CR, which provides important information regarding the synthesis of crystalline γ-Al 2 O 3 adsorbent, with selective adsorption ability for decontamination applications. [ABSTRACT FROM AUTHOR]

Object tracking is one of the most challenging problems in computer vision. Only Fast trackers can satisfy the real-time requirements and can be used in many artificial intelligence applications. Due to the impressive high-speed, correlation filters have received much attention within the field of object tracking. Recently, trackers using luminance information or color names for image description have been performed in a correlation filters framework. In this paper, we propose the usage of discriminative color descriptors to improve the tracking performance of the traditional correlation filters tracker. Discriminative color descriptors are compact and efficient. Moreover, our tracker incorporates scale estimation into the traditional correlation filters, which results in increased tracking performance. Extensive experiments demonstrate that the proposed tracker can obtain superior results compared to existing trackers using correlation filters and it is also able to outperform state-of-the-art trackers on the CVPR2013 object tracking benchmark. [ABSTRACT FROM AUTHOR]

• Co-MOF was synthesized in aqueous solution. • Co-MOF was positively charged at pH lower than 11.8. • Electrostatic and π–π stacking interactions contributed to the favorable adsorption of CR on Co-MOF. • Co-MOF had excellent recyclable performance. Wastewater discharged from the dye production and consumption process has a high chemical oxygen demand, high chroma, and complex structure. In this study, a boat shaped flaky cobalt-based metal–organic framework (Co-MOF) was synthesized in aqueous solution by using a green one-step precipitation strategy. This strategy exhibited favorable efficiency for the removal of Congo red (CR). Furthermore, ZIF-67 with a rhombic dodecahedral shape was synthesized in anhydrous methanol solvent through a one-step precipitation strategy. The effects of the contact time, adsorbent dosage, initial CR concentration, and pH value on the adsorption of CR were also investigated. Results indicated that the adsorption of CR by Co-MOF and ZIF-67 fitted well with the Langmuir model and pseudo-second-order kinetic model. The maximum adsorption capacities obtained for Co-MOF and ZIF-67 with the Langmuir model were 1019.06 and 1044.58 mg/g at 25 °C, respectively. The obtained equilibrium time was less than 5 min. Moreover, Co-MOF and ZIF-67 had the same removal capacities for CR. The adsorption mechanism was attributed to the strong electrostatic and π–π stacking interactions of CR with Co-MOF and ZIF-67. Thus, the proposed method is a facile and green method to synthesize Co-MOF for the efficient removal of organic dyes from aqueous solutions. [ABSTRACT FROM AUTHOR]

Phytoremediation is widely used for the restoration of aquatic environments. However, the phytoremediation effects and mechanisms of special submerged species of native aquatic plants, especially under low-temperature conditions, are not yet clear. In this study, two typical submerged plants, Myriophyllum aquaticum (M. aquaticum ; an exotic species) and Hippuris vulgaris (H. vulgaris ; a native species), in China were investigated for their phosphorus (P) removal efficiencies (RE p) and the related mechanisms of phytophysiology and microorganisms in a low-temperature incubator (10 °C during the day and 2 °C at night). At an initial P level of 0.5 mg L−1, the two plants exhibited similar RE p , with the highest values (73.5%–92.1%) observed on days 3–6. After 18 days, the residual P concentration in the water was less than the Grade III limit value (0.2 mg L−1; GB 3838–2002). However, M. aquaticum had a faster RE p velocity than H. vulgaris at an initial P level of 3.0 mg L−1, which was attributed to the mechanisms of plant and its interactions with microorganisms. Compared to the control group, the superoxide dismutase activity of H. vulgaris was significantly increased and its catalase activity was decreased, whereas for that of M. aquaticum was the opposite. Micro region X-ray fluorescence analysis revealed that there may be synergic absorption effects between P, S, and K, and antagonistic absorption action between P and Mn in H. vulgaris. In addition, Acinetobacter , Novosphingobium and Pseudomonas were enriched at 3.0 mg L−1 P level with these two plants, but Chlorophyta only accumulated with H. vulgaris , respectively. Overall, the native species, H. vulgaris, could replace the exotic M. aquaticum to efficiently remove P from polluted water at low temperatures. These findings provide a theoretical foundation for submerged plants P removal capabilities, and the protection of local ecosystem diversity at low temperatures. [Display omitted] • H. vulgaris can effectively replace M. aquaticum in removing P from water at low temperature. • Both H. vulgaris and M. aquaticum effectively removed P from water at low temperatures. • Plants and microorganisms accounted for 37.9–60.6% and 17.0–42.0% of P removal, respectively. • There may be synergic effects between P, S, and K, and antagonistic action between P and Mn in H. vulgaris. • Chlorophyta was enriched with H. vulgaris to remove P from water. [ABSTRACT FROM AUTHOR]