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This study explores the effectiveness of a botanical bioscrubber system using Golden Pothos (Epipremnum aureum) in hydroponic setups to mitigate common indoor atmospheric pollutants. Over a 100-day operation, levels of SO 2 , NO 2 , O 3 , TVOC, CO, CO 2 , PM 10 , and PM 2.5 were monitored, with a significant reduction in carbon-based compounds and particulate matter-. Notably, CO 2 and PM 2.5 removal efficiencies were significantly correlated with the foliar area, suggesting that the interaction between pollutants and plant leaves plays a crucial role in the phytoremediation process. In contrast, CO, PM 10 , and TVOC exhibited varied removal efficiencies, hinting the involvement of mechanisms beyond leaf interaction, such as adsorption in irrigation water or root system capture. The absence of significant correlations for PM 10 emphasized the need for further investigation into alternative removal processes, potentially mediated by the root system. Overall, our findings suggest that botanical bioscrubbers, particularly those utilizing Golden Pothos, hold promise for indoor air purification through plant-based systems. [Display omitted] • Implementation of botanical bioscrubber could enhances indoor air quality. • Hydroponic pots of Epipremnum aureum were used to treat indoor air pollutants. • Carbon-based species and particulate matter were primarily removed in the system. • The air/leaf interaction was the main removal mechanism of the system. • Active biofiltration offers a sustainable solution for indoor air improvement. [ABSTRACT FROM AUTHOR]