1. A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model.
- Author
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Nie, Binbin, Wang, Lu, Hu, Yichao, Liang, Shengxiang, Tan, Zhiqiang, Chai, Pei, Tang, Yongjin, Shang, Jingjie, Pan, Zhangsheng, Zhao, Xudong, Zhang, Xiaofei, Gong, Jianxian, Zheng, Chao, Xu, Hao, Wey, Hsiao-Ying, Liang, Steven H., and Shan, Baoci
- Subjects
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POSITRON emission tomography , *MACAQUES , *RHESUS monkeys , *BRAIN tomography , *PARTICLE physics - Abstract
Positron emission tomography (PET) is a non-invasive imaging tool for the evaluation of brain function and neuronal activity in normal and diseased conditions with high sensitivity. The macaque monkey serves as a valuable model system in the field of translational medicine, for its phylogenetic proximity to man. To translation of non-human primate neuro-PET studies, an effective and objective data analysis platform for neuro-PET studies is needed. A set of stereotaxic templates of macaque brain, namely the Institute of High Energy Physics & Jinan University Macaque Template (HJT), was constructed by iteratively registration and averaging, based on 30 healthy rhesus monkeys. A brain atlas image was created in HJT space by combining sub-anatomical regions and defining new 88 bilateral functional regions, in which a unique integer was assigned for each sub-anatomical region. The HJT comprised a structural MRI T1 weighted image (T1WI) template image, a functional FDG-PET template image, intracranial tissue segmentations accompanied with a digital macaque brain atlas image. It is compatible with various commercially available software tools, such as SPM and PMOD. Data analysis was performed on a stroke model compared with a group of healthy controls to demonstrate the usage of HJT. We have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research. • Developing a population stereotaxic PET template, named HJT, for the macaque brain. • Identifying 88 bilateral functional regions in HJT. • Performance of HJT on the platform of commercially available software such as SPM and PMOD. • Application of HJT in voxel-wised analysis of stroke macaque model. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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