1. Growing Trends of Contralateral Prophylactic Mastectomy and Reconstruction in Young Breast Cancer.
- Author
-
Chen, Hongliang, Zhang, Peng, Zhang, Mingdi, Wang, Maoli, Bai, Fang, and Wu, Kejin
- Subjects
- *
MASTECTOMY , *MAMMAPLASTY , *BREAST cancer , *LUMPECTOMY , *CHI-squared test - Abstract
The aim of this study was to evaluate the trends of surgical treatments among young patients in T 1 N 0-1 M 0 stage based on the Surveillance, Epidemiology, and End Results database. Patients aged less than 40 y diagnosed between 1998 and 2015 were enrolled, with tumors in T 1 N 0-1 M 0 stage and not located in the central area. Differences in clinical-pathological characteristics were evaluated using chi-square tests. Multivariate logistic regression was used to measure the various factors associated with contralateral prophylactic mastectomy (CPM). Independent prognostic factors were evaluated by Cox model. The total rate of breast-conserving surgery (BCS) was 51.6%, which declined from 64.5% in 1998 to 39.6% in 2015. The total rate of CPM was 22.7%, which increased from 3.7% in 1998 to 38.7% in 2014 despite a decline to 32.7% in 2015. Meanwhile, the rate of reconstruction increased in line with that of CPM, from 9.4% in 1998 to 35.0% in 2015. There was a trend of increasing use of implant-based reconstruction. Significant higher odds of CPM were found in recent year of diagnosis between 2010 and 2015 and in implant-based reconstruction. Patients undergoing CPM had similar survival outcomes compared with those undergoing BCS and unilateral mastectomy, whereas those undergoing BCS had better survival outcomes compared with those undergoing unilateral mastectomy. A trend of growing preference for CPM and reconstruction was observed among young patients in early stage in recent years without survival benefits. Efforts should be made to promote efficient communication and evidence-based decision-making. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF