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Start Over Author "Xiong, Xin-Xin" Publisher academic press inc.
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1. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation.

Author

Liu, Ju Mei, Pan, Feng, Li, Li, Liu, Qian Rong, Chen, Yong, Xiong, Xin Xin, Cheng, Kejun, Yu, Shang Bin, Shi, Zhi, Yu, Albert Cheung-Hoi, and Chen, Xiao Qian

Subjects
*PEPPER (Spice), *PLANT extracts, *GLIOBLASTOMA multiforme treatment, *REACTIVE oxygen species, *BIOACCUMULATION, *PROTEIN kinases, *ASTROCYTES, *CELL-mediated cytotoxicity, *THERAPEUTICS
Abstract

Highlights: [•] Piperlongumine (PL) selectively kills GBM cells but not normal astrocytes. [•] PL kills GBM cells via ROS accumulation. [•] PL activates JNK and p38 differentially in GBM cells via ROS accumulation. [•] JNK and p38 activation contributes to PL’s cytotoxicity in GBM cells. [Copyright &y& Elsevier]

Published
2013
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