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A series of Ca 3 Ti 2 O 7 :Eu 3+ , Ca 3 Ti 2 O 7 :Eu 3+ , Bi 3+ , Ca 3 Ti 2 O 7 :Eu 3+ , R + , and Ca 3 Ti 2 O 7 :Eu 3+ , Bi 3+ , R + ( R + =Li + , Na + , and K + ) phosphors are synthesized by solid-state reaction method in air. All phosphors show bright red emissions centered at ~617 nm upon excitation with UV light of 397 nm. Bi 3+ is a sensitizer for the luminescence of Eu 3+ , and can improve significantly the PL intensity of Ca 3 Ti 2 O 7 :Eu 3+ phosphor due to energy transfer between Bi 3+ and Eu 3+ ions. The sensitization mechanism is investigated and discussed by energy level diagrams of Bi 3+ and Eu 3+ ions. R + ion is used as the charge compensator to improve the luminescence intensity of Ca 3 Ti 2 O 7 :Eu 3+ and Ca 3 Ti 2 O 7 :Eu 3+ , Bi 3+ phosphors, and their PL intensities are enhanced in the sequence K + →Na + →Li + . These phosphors can be promising red emitting candidate for white LED with a ~397 nm near UV chip excitation owing to the high brightness. [ABSTRACT FROM AUTHOR]

Abstract: La2BaZnO5:Nd3+ phosphors are synthesized by a conventional high temperature solid state reaction method, and its crystal structure and luminescence properties are investigated. Photoluminescence bands peaking at ~496, 540, 630, 670, 905, 1070, and 1350nm of La2BaZnO5:Nd3+ phosphors are observed at room temperature due to f–f transition of Nd3+ ion. The optimum Nd3+ doped concentration is ~0.03. Lifetimes of La1.97BaZnO5:0.03Nd3+ phosphor with 496 and 1070nm monitoring wavelengths are ~280 and 250µs, respectively. The luminescence mechanism is explained by using simplified energy lever diagram of Nd3+ ion. La2BaZnO5:Nd3+ material can be applied to powerful solid-state lasers as high efficient light sources. [Copyright &y& Elsevier]

Prostate cancer (PCa) refers to malignant tumors derived from prostate epithelial cells, whose morbidity and mortality rates have been increasing every year. Although new drugs for treating prostate cancer continue to emerge, the unclear mechanism underlying drug targets limits this therapy, thereby constraining identification of effective therapeutic targets. Although GDP dissociation inhibitor 2(GDI2) is highly expressed and closely associated with occurrence and development of many tumors, its role in prostate cancer remains unclear. In this study, we investigated the role of GDI2 and elucidated its underlying mechanism of action in prostate cancer. Moreover, we screened chemotherapeutic drugs that affect GDI2 expression with a view of identifying novel targets for diagnosis and treatment of prostate cancer. We performed sequence analyses and functional assays to precisely elucidate the GDI2 role in prostate cancer. Moreover, we induced tumorigenesis in nude mice to verify the role of GDI2 in viv o. Finally, we used the CCK8 assay to ascertain the most suitable IC 50 across the three drugs and performed quantitative real time polymerase chain reaction (qRT-PCR) and Western Blot to analyze the effects of drugs on expression of GDI2, p75NTR, and p -NFκB. GDI2 was up-regulated in prostate cancer cells and tissues. Knocking down GDI2 suppressed cell proliferation but promoted cell apoptosis. Interestingly, knocking down GDI2 activated the p75NTR signaling pathway, indicating, for the first time, that p75NTR is negatively correlated with GDI2 expression. Taken together, these results indicate that GDI2 is a therapeutic target of paclitaxel. Knocking down of GDI2 inhibits cell proliferation and promotes cell apoptosis via the p75NTR signaling pathway in prostate cancer. Notably, paclitaxel inhibits GDI2 expression, implying that GDI2 may be a promising therapeutic target in prostate cancer. • We firstly discovered that GDI2 is one of the therapeutic targets of paclitaxel in PC3 and DU145 cells. • We identified the role of GDI2 in the progression of prostate cancer for the first time. • We revealed that p75NTR is negatively regulated by GDI2 in prostate cancer. [ABSTRACT FROM AUTHOR]

Novel CaWO 4 :Eu 3+ , Mn 2+ red phosphor is synthesized by solid-state reaction method in air. CaWO 4 :Eu 3+ , Mn 2+ phosphor with excitation 268 and 394 nm emits red light with chromaticity coordinates (x = 0.6403, y = 0.3593). The strongest emission bands peaking at ∼615 nm is attributed to 5 D 0 → 7 F 2 of Eu 3+ ion. Strong excitation band peaking at ∼394 nm indicates that the phosphor may be excited by near UV (∼394 nm) chip. Emission intensity of CaWO 4 :Eu 3+ , Mn 2+ phosphor with excitation 268 nm is ∼2 times stronger than that of CaWO 4 :Eu 3+ phosphor owing to energy transfer between Eu 3+ ion and Mn 2+ ion. Energy transfer from WO 4 2 − group and Eu 3+ ion to Mn 2+ ion in CaWO 4 :Eu 3+ , Mn 2+ phosphor may be explained via luminescence properties. Luminous mechanism is analyzed by energy level diagrams of WO 4 2 − group, Mn 2+ and Eu 3+ ion. The paper content is helpful to develop and research other novel phosphors. [ABSTRACT FROM AUTHOR]