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A novel naphthalene diimide-based compound, designated as [Zn(BINDI) 0.25 ·(C 2 H 5 NO)] n (1), has been successfully synthesized under solvothermal conditions, utilizing N, N′-bis(5-isophthalic acid) naphthalenediimide (H 4 BINDI) and Zn(NO 3) 2 ·6H 2 O as raw materials. Single crystal X-ray diffraction analysis revealed that compound 1 forms a 3D structure, with BINDI4− and C 2 H 5 NO− serving as organic ligands and Zn(II) as the center metal ion. Notably, upon exposure to a 300 W xenon lamp, compound 1 rapidly transitions from orange to dark blue within 5 s. Furthermore, as the duration of irradiation increases, 1 exhibits photocontrolled fluorescence properties. Additionally, it possesses the capability to detect ammonia vapor and triethylamine. The synthesized compound 1 not only has reversible photochromic properties, but also has visible color change to ammonia vapor and triethylamine, which can be used as one of the color-changing materials for detecting ammonia vapor and triethylamine. [Display omitted] • A novel color-changing compound based on naphthalimide was synthesized. • Compound 1 has rapid retrochromic properties. • The ability to detect ammonia vapor and triethylamine. [ABSTRACT FROM AUTHOR]

Highlights: [•] The 2000–2634aa region of HUWE1 mediates the interaction with BRCA1 degron. [•] HUWE1 promotes the degradation of BRCA1 through the ubiquitin–proteasome pathway. [•] HUWE1 expression is inversely correlated with BRCA1 in breast cancer cells. [•] RNAi inhibition of HUWE1 confers increased resistance of MCF-10F cells to IR and MMC. [ABSTRACT FROM AUTHOR]

Highlights: [•] The 2000–2634aa region of HUWE1 mediates the interaction with BRCA1 degron. [•] HUWE1 promotes the degradation of BRCA1 through the ubiquitin–proteasome pathway. [•] HUWE1 expression is inversely correlated with BRCA1 in breast cancer cells. [•] RNAi inhibition of HUWE1 confers increased resistance of MCF-10F cells to IR and MMC. [ABSTRACT FROM AUTHOR]