1. Prospective non-interventional multicentre observational trial of first-line anti-cancer treatment in patients with metastatic renal cell cancer in Belgium
- Author
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Philip R. Debruyne, Tijl Vermassen, Thierry Gil, Alain Bols, Randal D'hondt, Nicolaas Lumen, D. Schrijvers, Sylvie Rottey, Jeroen Mebis, Jean-Pascal Machiels, Denis Schallier, Natasha Cornelis, and Laboratory of Molecular and Medical Oncology
- Subjects
Adult ,Male ,Sorafenib ,medicine.medical_specialty ,FIRST LINE TREATMENT ,Antineoplastic Agents ,urologic and male genital diseases ,Choice Behavior ,Pazopanib ,Belgium ,Renal cell carcinoma ,Internal medicine ,Carcinoma ,Humans ,Medicine ,Prospective Studies ,Carcinoma, Renal Cell ,Aged ,Aged, 80 and over ,Everolimus ,business.industry ,Sunitinib ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Temsirolimus ,Surgery ,Female ,business ,medicine.drug - Abstract
Objectives: Renal cell carcinoma (RCC) accounts for 2·4% of all new cancers in Belgium. Over the past decade, the armamentarium for systemic therapy of metastatic RCC (mRCC) has undergone important changes with implementation of targeted therapies directed against pathways involved in the pathogenesis of RCC. We describe first-line treatment choice of a group of patients in nine Belgian oncology centers between October 2009 and November 2012. Methods: A clinical report form was established to assess patient characteristics, Karnofsky performance score, Memorial Sloan-Kettering Cancer Center risk criteria (MSKCC) and first-line therapy of mRCC patients. Choice of therapy and starting dose was analyzed before and after reimbursement of pazopanib in Belgium. Results: Ninety-six patients were eligible for the study. Non-smokers accounted for 53% of the patients. Seventy-three per cent of the patients had 0 or 1 MSKCC criteria in the group of patients that started treatment more than 1 year after initial diagnosis. In the group of patients that started therapy less than 1 year after diagnosis, 85% had 2 or more MSKCC criteria. This difference was statistically significant (P
- Published
- 2014