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1. [Effect of fibroblast growth factor and nerve growth factor on the cellular proliferation and functional activity of isolated islands of Langerhans].

Author

Sadovnikova NV, Komolov IS, Fedotov VP, Dungar A, and Besch V

Subjects
Animals, Animals, Newborn, Cell Division drug effects, Cells, Cultured, Insulin metabolism, Insulin Secretion, Islets of Langerhans cytology, Islets of Langerhans metabolism, Rats, Rats, Inbred Lew, Rats, Inbred Strains, Fibroblast Growth Factors pharmacology, Islets of Langerhans drug effects, Nerve Growth Factors pharmacology
Abstract

The effects of fibroblast growth factor (FGF) and nerve growth factor (NGF) on DNA synthesis and insulin secretion were studied in 4-5-day cultures of the isolated neonatal rat islets. FGF (0.1 ng/ml) stimulated significantly the incorporation of 3H-thymidine into DNA of the isolated islets, but failed to change either insulin content in the islets or the rate of insulin secretion. NGF (0.1-1000 ng/ml) did not affect the above parameters. The responses of the islets of Langerhans to increasing concentrations of glucose and isobutylmethylxanthine were not modified after prolonged exposure to NGF. The role of FGF and NGF in the regulation of proliferation and secretory process in pancreatic islet cells is discussed.

Published
1988

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