1. Association between BRAF expression in circulating tumor cells and the clinical feature of patients with multiple myeloma.
- Author
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Tang JX, Zhang JH, Zhou KB, Li WT, Wang JY, Li Q, Yan FX, and Xiao D
- Subjects
- Albumins, Biomarkers, Biomarkers, Tumor genetics, Epithelial-Mesenchymal Transition genetics, Humans, Prognosis, Multiple Myeloma genetics, Neoplastic Cells, Circulating metabolism, Proto-Oncogene Proteins B-raf genetics
- Abstract
Multiple myeloma (MM) is the most common hematological malignancy with uncontrolled proliferation of monoclonal plasma cells. Despite treatment improvements, MM remains an incurable disease for most patients. Therefore, promising molecular markers are required for MM treatment decisions. In the present study, we explored the relationship between the BRAF expression in circulating tumor cells (CTCs) and the clinical features of patients with MM. The results showed that CTCs were associated with MM staging, and the expression of BRAF was associated with different CTCs. Moreover, the BRAF gene was correlated with patients' white blood cells, blood albumin levels, and Eastern Cooperative Oncology Group (ECOG) score. BRAF expression positively correlated with total CTCs, hybrid CTCs, and mesenchymal CTCs. Taken together, CTCs tightly correlated with the clinical stages and characteristics of MM. Our findings may provide a promising prognosis biomarker for MM treatment decisions.
- Published
- 2022
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