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Start Over Publisher african journals online (ajol)
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2. Evaluation of the anti-oxidant and anti-angiogenic effects of Sphenocentrum Jollyanum Pierre

Author

R Nia, DH Paper, EE Essien, KC Iyadi, AIL Bassey, AB Antai, and G Franz

Subjects
Stem bark, Chloroform, Traditional medicine, Angiogenesis, DPPH, Anti angiogenic, General Medicine, Fractionation, Anti oxidant, Toxicology, chemistry.chemical_compound, chemistry, General Pharmacology, Toxicology and Pharmaceutics, Sphenocentrum jollyanum
Abstract

The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti -angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC 50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 μg/pellet) on DDPH and anti -angiogenesis assays respectively. Further fractionation of the stem bark revealed the chloroform fraction to have the highest IC 50 1.54 ± 0.15 and the most important score on anti - angiogenesis assay with 1.3 ± 0.10 at 250 μg/pellet when serially diluted between 250 and 36.2 μg/pellet. Moreover, the effects were found to be dose-dependent. These results bring to the fore the need for further studies towards confirming the anti -oxidant and anti-angiogenic potentials of the plant as well as identifying and characterizing the active principles for drug development. African Journal of Biomedical Research Vol. 8(1) 2005: 4750

Published
2006