Animals, Diffusion, Drug Carriers, Ethylene Dichlorides pharmacology, Hydra drug effects, Hydra physiology, Molecular Weight, Neuropeptides pharmacokinetics, Paper, Pyrrolidonecarboxylic Acid analogs & derivatives, Regeneration drug effects, Regeneration physiology, Serum Albumin pharmacology, Time Factors, Vitamin A pharmacokinetics, Polyvinyls pharmacology
Abstract
The possibility to use polymer carrier for transport of retinol (R) and the peptide enhancing regeneration of head section of Hydra (PH) has been studied. Efflux of R occurs both through intact polymer and through pores formed in the polymer by albumin, whereas PH is not able to penetrate the polymer and its rate of efflux is determined by the amount of albumin added. The efflux of both R and PH changes with time in a stepwise manner. The total yield of R and PH after 37 days varied in the range of 17 to 40% and 1 to 95%, respectively, in different experimental conditions.