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Introduction. Spitz nevus is a benign melanocytic lesion, most frequently met in children and in the young adult, at the level of the head and of the extremities, with a rapid evolution (months), that worries both the family and the doctor. Aim. To highlight the difficulties in diagnosing clinically, dermoscopically and histopathologically a lesion that may resemble to a melanoma. Material and methods. We present two cases of Spitz nevus, appeared at the age of 10 and 16, respectively, as a blackish pigmented lesion and a pink, non-pigmented one, for which a consultation at the clinic was demanded, for the suspicion of malignity. Both lesions were clinically, dermoscopically and histopathologically evaluated. Results. The suspicion of malignity being totally eliminated for the non pigmented one, classified as a classical non pigmented Spitz nevus; on the other hand, the pigmented lesion could only be classified as an atypical Spitz nevus (spitzoid tumor with uncertain malignant potential). Conclusions: Diagnosing Spitz nevus continues to be a clinical, dermoscopic and, last but not least, histopathological challenge, and the surgical excision is recommended in most cases. [ABSTRACT FROM AUTHOR]

The ongoing coronavirus disease 2019 (COVID-19) outbreak was declared a pandemic by the World Health organization in early March 2020. The disease typically presents with viral respiratory symptoms that could progress to acute respiratory distress syndrome. Emerging evidence suggests different possible dermatologic manifestations of COVID-19, including: acral lesions (pernio-like, pseudo-chillblain), vesicular eruptions, macular and papular exanthema, urticaria, livedoid, purpuric and petechial rashes. However, specific skin manifestations of the COVID-19 disease have not yet been clearly established and the relationship between the appearance of skin lesions and SARS-CoV-2 infection is still unclear. These highly variable skin changes could represent a direct consequence of the viral infection, an immunological response to viral nucleotides, adverse reactions to drugs frequently used for the treatment of COVID-19, or other disorders. In a global effort to comprehend the exact cutaneous features of COVID-19, several international dermatological societies have initiated nationwide studies to analyze COVID-19 cutaneous manifestations during this pandemic. This paper represents a literature review of the scientific data available on the clinical characteristics and symptoms of the cutaneous manifestations associated with COVID-19. Such findings are extremely useful in establishing if dermatological manifestations in COVID-19 patients could harbor a diagnostic significance and subsequently be used as prognostic factors for outcomes of COVID-19. [ABSTRACT FROM AUTHOR]

Juvenile xanthogranuloma represents the most common form of non-Langerhans cell histiocytosis. It is tipically a childhood disorder, over 80% of cases developing in the first year of life. Adult onset xanthogranuloma is instead exceedingly rare; our literature research revealed a total number of only 35 cases reported to date. Cases with multiple cutaneous lesions occurring during adulthood are even rarer. The pathogenesis of the disease is incompletely understood and the possibility of extracutaneous involvement is uncertain.Although adult xanthogranulomatosis is not considered a paraneoplastic phenomenon, association with haematological malignancies is very frequent, therefore patients should be thoroughly investigated and closely monitored. We report a case of multiple xanthogranulomas developing in an otherwise healthy adult female patient and review the literature regarding this uncommon disease. [ABSTRACT FROM AUTHOR]