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Oral hairy leukoplakia is a lesion of the oral mucosa caused by infection with the Epstein-Barr virus. It was first described in 1984 in homosexual men infected with the human immunodeficiency virus (HIV) but it was later associated also with other forms of immunosuppression. In HIV infected patients this lesion proved to be associated with progression to acquired immunodeficiency syndrome (AIDS). We report the case of a 32 year-old patient that presented for acneiform lesions on the face and thorax. Apart from acne vulgaris lesions, the clinical examination revealed irregular, adherent, undetachable and corrugated white plaques located on the tongue and oral mucosa. The presumptive diagnosis was oral hairy leukoplakia. Testing for HIV was recommended and the result was positive. CD4 cell count at the time of treatment initiation was 7 cells/mm3. After three months of antiretroviral therapy, the lesions resolved completely. The particularity of the case resides in the peculiar distribution and extent of the lesions and the late diagnosis of HIV/AIDS. In this case, oral hairy leukoplakia was the single marker of immunosuppression. [ABSTRACT FROM AUTHOR]

Buschke-Löwenstein tumor (BLT) is a rare premalignant disorder, with a considerable potential of malignant transformation into squamous cell carcinoma; HPV infection (especially HPV 6 and HPV 11) have an important role in the ethiopathogeny of the disease, along with immunosuppression- usually caused by HIV virus, a frequently encountered association. We report on the case of a 47 year old male patient who addresses our clinic for the occurrence of a giant tumoral lesion located in the intergluteal cleft, which had rapidly evolved despite the repeatedly negative HIV testing. The histopathologic examination confirms the clinical diagnosis of BLT; wide surgical excision of the tumor with safety margins was not followed by recurrence, during a follow-up period that exceeded 12 months. The case is distinguished through the large dimensions of the tumor, the extremely rare anatomical situation and the rapid evolution, despite the absence of HIV immunosuppression. [ABSTRACT FROM AUTHOR]