1. Increased circulating choline, L-carnitine and TMAO levels are related to changes in adiposity during weight loss: role of the gut microbiota?
- Author
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Emanuel E. Canfora, Ellen E. Blaak, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Humane Biologie
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Diet, Reducing ,Adipose Tissue, White ,Trimethylamine N-oxide ,Disease ,METABOLISM ,Gut flora ,Choline ,Methylamines ,03 medical and health sciences ,chemistry.chemical_compound ,Weight loss ,Carnitine ,Internal medicine ,Weight Loss ,Humans ,Medicine ,Adiposity ,Caloric Restriction ,biology ,business.industry ,Body Weight ,Type 2 Diabetes Mellitus ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,Obesity ,Gastrointestinal Microbiome ,Editorial ,Treatment Outcome ,030104 developmental biology ,Endocrinology ,Diabetes Mellitus, Type 2 ,chemistry ,OBESITY ,DEFICIENT DIET ,Female ,Waist Circumference ,medicine.symptom ,Energy Metabolism ,TRIMETHYLAMINE-N-OXIDE ,business ,medicine.drug - Abstract
Adiposity and the gut microbiota are both related to the risk of type 2 diabetes. We aimed to comprehensively examine how changes induced by a weight-loss diet intervention in gut microbiota-related metabolites, such as trimethylamineThis study included 510 overweight and obese individuals who were randomly assigned one of four diets varying in macronutrient intake. We examined associations of 6-month changes in blood metabolites (TMAO, choline, and l-carnitine) with improvements in body weight (BW), waist circumference (WC), body fat composition, fat distribution, and resting energy expenditure (REE).Individuals with a greater reduction of choline (Overweight and obese individuals who showed decreases in circulating choline or l-carnitine levels achieved greater improvements of adiposity and energy metabolism by eating a low-calorie weight-loss diet, suggesting that such metabolites are predictive of individuals' response to the treatment. Further investigations are necessary to confirm our findings, particularly in a population with prediabetes that is more representative of the U.S. population with obesity.
- Published
- 2018
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