1. Quality of life in patients with Marfan syndrome: a cross-sectional study of 102 adult patients
- Author
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Rhoia Neidenbach, Ulrike Gundlach, Sebastian Freilinger, S. Achenbach, Harald Kaemmerer, Caroline Andonian, Michael Weyand, Nicole Nagdyman, Jürgen Beckmann, Peter Ewert, Lars Pieper, and Jörg Schelling
- Subjects
musculoskeletal diseases ,Pediatrics ,medicine.medical_specialty ,business.industry ,Cross-sectional study ,Disease ,humanities ,ddc ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,EQ-5D ,Cohort ,Medicine ,Anxiety ,cardiovascular diseases ,030212 general & internal medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Psychosocial ,030217 neurology & neurosurgery ,Depression (differential diagnoses) ,Original Article on Current Management Aspects in Adult Congenital Heart Disease (ACHD): Part III - Abstract
BACKGROUND: Marfan syndrome (MFS) is a genetically determined multiorgan disease that leads to severe physiological and psychological impairments in adult life. Little consensus exists regarding quality of life (QOL) in individuals with MFS. The present study sought to investigate QOL in a representative cohort of adults with MFS. METHODS: Patient-reported outcome measures from a representative sample of 102 adults with MFS (39.3±13.1 years of age; 40.2% female) were retrospectively analyzed and compared with those from adults with different congenital heart defects (CHD), at the German Heart Center Munich. QOL was assessed using the updated five-level version of the EQ-5D. RESULTS: Differences between both populations were analyzed. Subjects affected by MFS reported an overall reduced QOL. Compared to CHD patients, individuals with MFS scored significantly lower in the dimensions of pain/discomfort, anxiety/depression, mobility and usual activities (P
- Published
- 2020