1. Increased circulating levels of vascular endothelial growth factor C can predict outcome in resectable gastric cancer patients
- Author
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Angelica Petrillo, Luca Pompella, Annamaria Auricchio, Maria Maddalena Laterza, Ferdinando De Vita, Michele Orditura, Fortunato Ciardiello, Jole Ventriglia, Giuseppe Tirino, Gennaro Galizia, B. Savastano, Annalisa Pappalardo, Petrillo, Angelica, Laterza, Maria Maddalena, Tirino, Giuseppe, Pompella, Luca, Pappalardo, Annalisa, Ventriglia, Jole, Savastano, Beatrice, Auricchio, Annamaria, Orditura, Michele, Ciardiello, Fortunato, Galizia, Gennaro, and De Vita, Ferdinando
- Subjects
medicine.medical_specialty ,Prognostic factor ,Vascular endothelial growth factor C (VEGF-C) ,Gastroenterology ,Regional lymph node involvement ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Tumor stage ,Overall survival ,Medicine ,Gastric cancer (GC) ,business.industry ,Lymphangiogenesi ,Healthy subjects ,Cancer ,medicine.disease ,Lymphangiogenesis ,Oncology ,Vascular endothelial growth factor C ,030220 oncology & carcinogenesis ,Serum vascular endothelial growth factor-C (serum VEGF-C) ,Original Article ,030211 gastroenterology & hepatology ,business - Abstract
Background: Neoangiogenesis has proven to be a relevant pathogenetic mechanism in gastric cancer (GC) and lymphatic spread represents an important well-known prognostic factor. Vascular endothelial growth factor C (VEGF-C) plays a key role in lymphangiogenesis and its blood levels in GC patients are easily measurable. This analysis aimed to investigate the prognostic role of preoperative VEGF-C blood levels.Methods: VEGF-C serum levels were determined by enzyme-linked immunoadsorbent assay (ELISA) in 186 patients observed at our institution from January 2004 until December 2009 and 82 healthy subjects. Statistical analyses were performed using SPSS 21.0.Results: VEGF-C levels were significantly higher in GC patients (median: 287.4 pg/mL; range, 76.2-865.2 pg/mL) than in the control group (median VEGF-C: 31 pg/mL; range, 12-97 pg/mL). A significant correlation between VEGF-C levels, T, N and tumor stage has been described. The median overall survival (OS) was statistically significantly higher in pts with low serum VEGF-C levels [median: not reached (NR) vs. 26 months; P
- Published
- 2019
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