1. Clinical characteristics of patients with chronic obstructive pulmonary disease assessed using GOLD 2016 and GOLD 2018 classifications: a cross-sectional study in China.
- Author
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Jian W, Zeng H, Zhang X, Yun C, Xu Z, Chen Y, Shi G, Wang Y, Li Y, and Zheng J
- Abstract
Background: In 2017, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) removed spirometry as a criterion for classifying GOLD risk groups (A-D, low-high risk)., Methods: In this cross-sectional observational study in China, we used the GOLD 2016 (spirometry included) and 2018 (spirometry eliminated) criteria for classifying GOLD risk groups to describe: the proportion of patients with chronic obstructive pulmonary disease (COPD) in each GOLD risk group; disease severity; demographics and comorbidities. Patients aged ≥40 years with a clinical COPD diagnosis for ≥1 year were included. During a single study visit, patients completed the COPD assessment test, modified Medical Research Council (mMRC) dyspnea scale assessment, and spirometry tests. Demographics, medical history, and treatment data were recorded., Results: In total, 838 patients were included. Most patients were male (86.4%), ≥65 years old (58.6%), and current or former smokers (78.5%). By GOLD 2016, the highest proportion of patients were Group D (42.8%), followed by B (28.2%). By GOLD 2018, the highest proportion of patients were Group B (57.3%), followed by A (25.5%). A total of 296 patients (35.3%) were reclassified, either from Group C to Group A or from Group D to Group B. Overall, 36.2% of patients were receiving treatment concordant with GOLD 2016 recommendations; 34.1% were not receiving any inhaled medication., Conclusions: The distribution of COPD severity shifted from a high-risk category (by GOLD 2016) to a low-risk category (by GOLD 2018). The high proportion of patients not receiving maintenance medication reflects a high level of under-treatment of the disease., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/jtd-21-255). All authors declare that the present manuscript was supported by GlaxoSmithKline plc. in funding, medical writing, and article processing charges. WJ reports grant from GlaxoSmithKline (China) R&D Company Limited (GlaxoSmithKline plc. study 207136) and the Ministry of Chinese Science and Technology National Key R&D program (2018YFC1311900), outside the submitted work. JZ has participated in advisory boards and speakers’ bureaus for AstraZeneca and Boehringer Ingelheim. At time of study conduct, YL and YW were employees of GlaxoSmithKline plc., reporting personal fees. Editorial support (in the form of writing assistance, collating author comments, assembling tables/figures, grammatical editing, and referencing) was provided by Varkha Agrawal, PhD, of Tata Consultancy Services (India), and Bonnie Nicholson, PhD, of Ashfield MedComms (Macclesfield, UK), an Ashfield Health company, and was funded by GlaxoSmithKline plc., (2021 Journal of Thoracic Disease. All rights reserved.)
- Published
- 2021
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