1. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
- Author
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Cisca Wijmenga, Mihai G. Netea, Hendrik G. Stunnenberg, Ali Aghajanirefah, Nagesha A.S. Rao, Frances Burden, Aylwin Ng, Kim Berentsen, Sadia Saeed, Jacqueline M. Ratter, Hindrik H. D. Kerstens, Jessica Quintin, Menno ter Huurne, Amit Mandoli, Nilofar Sharifi, Kate Downes, Tom van Schaik, Willem H. Ouwehand, Martijn van der Ent, Colin Logie, Ramnik J. Xavier, Shih-Chin Cheng, Filomena Matarese, Joost H.A. Martens, Evangelos J. Giamarellos-Bourboulis, Leo A. B. Joosten, Eva M. Janssen-Megens, Mattia Frontini, Vinod Kumar, Jos W. M. van der Meer, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Radboud university [Nijmegen], Radboud University Medical Center [Nijmegen], Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University of Cambridge [UK] (CAM), University of Groningen [Groningen], National and Kapodistrian University of Athens (NKUA), and Massachusetts Institute of Technology (MIT)
- Subjects
MESH: Cell Differentiation ,LIVER X RECEPTOR ,REGULATORY ELEMENTS ,[SDV]Life Sciences [q-bio] ,Secondary infection ,NF-KAPPA-B ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Biology ,MESH: Monocytes ,[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity ,DENDRITIC CELLS ,03 medical and health sciences ,MESH: Inflammasomes ,0302 clinical medicine ,HOST-DEFENSE ,INFLAMMATION ,Immunity ,medicine ,IRAK-M ,HUMAN GENOME ,MESH: Animals ,MESH: Epigenesis, Genetic ,Epigenetics ,Molecular Biology ,MESH: Mice ,Transcription factor ,030304 developmental biology ,GENE-EXPRESSION ,0303 health sciences ,MESH: Humans ,Multidisciplinary ,Innate immune system ,MESH: beta-Glucans ,Monocyte ,MESH: Macrophages ,Inflammasome ,MESH: Transcription Factors ,MESH: Deoxyribonuclease I ,MESH: Genomic Imprinting ,TRANSCRIPTION FACTORS ,medicine.anatomical_structure ,MESH: Binding Sites ,030220 oncology & carcinogenesis ,Monocyte differentiation ,Immunology ,MESH: Immunologic Memory ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,MESH: Immunity, Innate ,medicine.drug - Abstract
A BLUEPRINT of immune cell development To determine the epigenetic mechanisms that direct blood cells to develop into the many components of our immune system, the BLUEPRINT consortium examined the regulation of DNA and RNA transcription to dissect the molecular traits that govern blood cell differentiation. By inducing immune responses, Saeed et al. document the epigenetic changes in the genome that underlie immune cell differentiation. Cheng et al. demonstrate that trained monocytes are highly dependent on the breakdown of sugars in the presence of oxygen, which allows cells to produce the energy needed to mount an immune response. Chen et al. examine RNA transcripts and find that specific cell lineages use RNA transcripts of different length and composition (isoforms) to form proteins. Together, the studies reveal how epigenetic effects can drive the development of blood cells involved in the immune system. Science , this issue 10.1126/science.1251086 , 10.1126/science.1250684 , 10.1126/science.1251033
- Published
- 2014
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