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Your search keyword '"Pouleur, H."' showing total 42 results
Start Over Author "Pouleur, H." Publisher amer heart assoc
42 results on '"Pouleur, H."'

2. Failure of Beta(1)-blockade To Prevent Remodeling in Ischemic Left-ventricular Dysfunction

Author

UCL - MD/FSIO - Département de physiologie et pharmacologie, Hager, D., Hayashida, W., Chapelle, F., van Eyll, Christian, Stoleru, L., Etienne, Jacques, Vannueten, L., Pouleur, H., Rousseau, MF., UCL - MD/FSIO - Département de physiologie et pharmacologie, Hager, D., Hayashida, W., Chapelle, F., van Eyll, Christian, Stoleru, L., Etienne, Jacques, Vannueten, L., Pouleur, H., and Rousseau, MF.

Published
1994

3. Analysis of the Mechanisms Underlying the Improvement in Ejection Fraction During Beta-blockade Therapy in Ischemic Left-ventricular Dysfunction

Author

UCL - MD/FSIO - Département de physiologie et pharmacologie, Hager, D., Hayashida, W., Chapelle, F., van Eyll, Christian, Stoleru, L., Etienne, Jacques, Vannueten, L., Pouleur, H., Rousseau, MF., UCL - MD/FSIO - Département de physiologie et pharmacologie, Hager, D., Hayashida, W., Chapelle, F., van Eyll, Christian, Stoleru, L., Etienne, Jacques, Vannueten, L., Pouleur, H., and Rousseau, MF.

Published
1994

4. Ace-inhibition Limits Infarct Expansion But Not Eccentric Hypertrophy Following Anterior Infarction With Successful Reperfusion

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - MD/MINT - Département de médecine interne, Hager, D., Renkin, Jean, Hayashida, W., van Eyll, Christian, Pouleur, H., Rousseau, MF., UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - MD/MINT - Département de médecine interne, Hager, D., Renkin, Jean, Hayashida, W., van Eyll, Christian, Pouleur, H., and Rousseau, MF.

Published
1994

5. Effects of the Angiotensin-converting Enzyme-inhibitor Enalapril On the Long-term Progression of Left-ventricular Dilatation in Patients With Asymptomatic Systolic Dysfunction

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/MINT - Département de médecine interne, Konstam, MA., Melin, Jacques, Kronenberg, MW., Rousseau, MF., Udelson, J.E., Stewart, D., Dolan, N., Edens, TR., Ahn, Sylvia, Kinan, D., Howe, DM., Kilcoyne, L., Metherall, J., Benedict, C., Yusuf, S., Pouleur, H., UCL - Cliniques universitaires Saint-Luc, UCL - MD/MINT - Département de médecine interne, Konstam, MA., Melin, Jacques, Kronenberg, MW., Rousseau, MF., Udelson, J.E., Stewart, D., Dolan, N., Edens, TR., Ahn, Sylvia, Kinan, D., Howe, DM., Kilcoyne, L., Metherall, J., Benedict, C., Yusuf, S., and Pouleur, H.

Abstract

Background. Patients with heart failure and reduced left ventricular (LV) ejection fraction (EF) manifest progressive LV dilatation, which is prevented by angiotensin converting enzyme (ACE) inhibitors. In patients with asymptomatic LV systolic dysfunction, in whom there is less activation of the renin-angiotensin system, ventricular remodeling might be less rapid and the benefit of ACE inhibitors less discernible. Methods and Results. One hundred eight patients enrolled in the Studies of Left Ventricular Dysfunction (SOLVD) Prevention Trial, with left ventricular ejection fraction less-than-or-equal-to 0.35 but without clinical heart failure, underwent radionuclide ventriculograms, and 49 underwent left heart catheterizations. Measurements were made before and after double-blinded randomization to enalapril (2.5 to 20 mg/d) or placebo. Repeated-measures analysis of all time points showed significant differences for change in end-diastolic volume (EDV) between enalapril and placebo groups. Significant difference between the enalapril and placebo groups (P<.05) was present for change in EDV at 1 year within the catheterization study and at a mean of 25 months within the radionuclide study. Radionuclide EDV increased in placebo patients (119+/-28 to 124+/-33 mL/m2, mean+/-SD) and decreased in enalapril patients (120+/-25 to 113+/-25 mL/m2). Differences between the two groups were significantly less than previously described in patients with symptomatic heart failure (P<.02), with less increase in LV volumes in the placebo group and less decrease in volumes in the enalapril group. Conclusions. Chronic ACE inhibitor treatment slows or reverses LV dilatation in patients with asymptomatic LV systolic dysfunction. Compared with symptomatic patients, asymptomatic patients manifest a slower rate of spontaneous LV dilatation and less reduction in LV volumes by enalapril.

Published
1993

6. Effects of Long-term Enalapril Therapy On Left-ventricular Diastolic Properties in Patients With Depressed Ejection Fraction

Author

UCL - MD/FSIO - Département de physiologie et pharmacologie, Pouleur, H., Rousseau, MF., van Eyll, Christian, Stoleru, L., Hayashida, W., Udelson, J.A., Dolan, N., Kinan, D., Gallagher, P., Ahn, Sylvia, Benedict, CR., Yusuf, S., Konstam, M., UCL - MD/FSIO - Département de physiologie et pharmacologie, Pouleur, H., Rousseau, MF., van Eyll, Christian, Stoleru, L., Hayashida, W., Udelson, J.A., Dolan, N., Kinan, D., Gallagher, P., Ahn, Sylvia, Benedict, CR., Yusuf, S., and Konstam, M.

Abstract

Background. The aim of the present study was to analyze the changes in left ventricular diastolic function that occur in patients with chronic severe left ventricular systolic dysfunction in the absence or presence of prolonged therapy with an angiotensin converting enzyme inhibitor. Methods and Results. Left ventricular function data (cineangiography plus Millar, frame-by-frame analysis) and right ventricular volumes (radionuclide angiography) were obtained at baseline and after an average follow-up of 12.4 months in 42 patients with a left ventricular ejection fraction of 35% or less. After baseline measurements, the patients were randomized to placebo (n=16) or enalapril (10 mg BID, n=26). In the placebo group, the changes in left ventricular function were characterized by increases in end-diastolic (159+/-43 to 170+/-44 ML/M2 ) and end-systolic (119+/-38 to 128+/-49 mL/M2) volumes accompanied by a downward and rightward shift of the diastolic pressure-volume relation. In contrast, decreases in end-diastolic (166+/-43 to 156+/-47 mL/M2 ) and end-systolic (125+/-43 to 111+/-42 mL/m2) volumes accompanied by a slight upward and leftward shift of the diastolic pressure-volume relation were noted in the enalapril group. These changes in left ventricular volumes were significantly different between groups (both P<.005) but were not attended by changes in left ventricular end-diastolic pressure, in time constant of isovolumic pressure decrease, or in right ventricular volumes. However, the chamber stiffness constant 8 decreased from 0.044+/-0.027 to 0.032+/-0.019 mL-1/m2 in the placebo group, whereas it increased insignificantly in the enalapril group (0.040+/-0.028 to 0.041+/-0.028 mL-1/m2). These changes in chamber stiffness constant beta between baseline and follow-up were significantly different between placebo and enalapril groups (P<.05). Another index of chamber compliance, DELTA V/DELTA P, also confirmed the presence of opposite changes in left ventricular chamb

Published
1993

7. Cardiac Mechanics During Development of Heart-failure

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - MD/MINT - Département de médecine interne, Pouleur, H., Melin, Jacques, Rousseau, MF., van Eyll, Christian, Youngblood, M., Yusuf, S., UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - MD/MINT - Département de médecine interne, Pouleur, H., Melin, Jacques, Rousseau, MF., van Eyll, Christian, Youngblood, M., and Yusuf, S.

Abstract

The changes in myocardial performance responsible for the progression from a stage of asymptomatic left ventricular dysfunction toward overt congestive heart failure are still poorly understood. Accordingly, using invasive methods, we examined the differences in baseline left ventricular function between a subgroup of patients enrolled in the treatment arm (presence of congestive heart failure) and in the prevention arm (asymptomatic patients) of the Studies of Left Ventricular Dysfunction. Methods and Results. High-fidelity left ventricular pressures and frame-by-frame angiographic volumes were simultaneously obtained under baseline conditions in 65 patients with left ventricular ejection fraction less-than-or-equal-to 35%. Sixteen patients had New York Heart Association congestive heart failure (class II or III), whereas the remaining 49 patients had no clinical signs of heart failure and did not receive therapy for this syndrome. A second set of data was obtained an average of 12.4 months later in 42 patients. The group with heart failure had significantly greater end-diastolic and end-systolic volumes than the asymptomatic group (both p <0.001), but the stroke index at rest was similar in both groups. Accordingly, ejection fraction was significantly lower in the heart failure group (19.6+/-7.0% versus 26.3+/-7.2%; p<0.02). Left ventricular end-diastolic pressure was greater and peak +dP/dt was lower in heart failure patients, but the difference did not reach statistical significance after Bonferroni correction for multiple comparisons. Moreover, the individual end-systolic stress/end-systolic volume data of the heart failure patients fell within the 95% confidence interval of the relation observed in the patients without heart failure both at baseline and after 1 year of follow-up irrespective of their changes in functional status. It was also noted that during follow-up, the changes in end-diastolic and end-systolic volumes correlated linearly, as if both dimen

Published
1993

10. Effects of the Angiotensin Converting-enzyme-inhibitor Enalapril On the Long-term Progression of Left-ventricular Dysfunction in Patients With Heart-failure

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/MINT - Département de médecine interne, Konstam, MA., Melin, Jacques, Rousseau, MF., Kronenberg, MW., Udelson, J.E., Stewart, D., Dolan, N., Edens, TR., Ahn, Sylvia, Kinan, D., Howe, DM., Kilcoyne, L., Metherall, J., Benedict, C., Yusuf, S., Pouleur, H., UCL - Cliniques universitaires Saint-Luc, UCL - MD/MINT - Département de médecine interne, Konstam, MA., Melin, Jacques, Rousseau, MF., Kronenberg, MW., Udelson, J.E., Stewart, D., Dolan, N., Edens, TR., Ahn, Sylvia, Kinan, D., Howe, DM., Kilcoyne, L., Metherall, J., Benedict, C., Yusuf, S., and Pouleur, H.

Abstract

Background. In patients with heart failure, activation of the renin-angiotensin system is common an has been postulated to provide a stimulus for further left ventricular (LV) structural and functional derangement. We tested the hypothesis that chronic administration of the angiotensin converting enzyme (ACE) inhibitor enalapril prevents or reverses LV dilatation and systolic dysfunction among patients with depressed ejection fraction (EF) and symptomatic heart failure. Methods and Results. We examined subsets of patients enrolled in the Treatment Trial of Studies of Left Ventricular Dysfunction (SOLVD). Fifty-six patients with mild to moderate heart failure underwent serial radionuclide ventriculograms, and 16 underwent serial left heart catheterizations, before and after randomization to enalapril (2.5-20 mg/day) or placebo. At 1 year, there were significant treatment differences in LV end-diastolic volume (EDV; p<0.01), end-systolic volume (ESV; p<0.005), and EF (p<0.05). These effects resulted from increases in EDV (mean +/- SD, 136+/-27 to 151+/-38 ml/m2) and ESV (103+/-24 to 116+/-24 ml/m2) in the placebo group and decreases in EDV (140+/-44 to 127+/-37 ml/m2) and ESV (106+/-42 to 93+/-37 ml/m2) in the enalapril group. Mean LVEF increased in enalapril patients from 0.25+/-0.07 to 0.29+/-0.08 (p<0.01). There was a significant treatment difference in LV end-diastolic pressure at 1 year (p<0.05), with changes paralleling those of EDV. The time constant of LV relaxation changed only in the placebo group (p<0.01 versus enalapril), increasing from 59.2+/-8.0 to 67.8+/-7.2 msec. Serial radionuclide studies over a period of 33 months showed increases in LV volumes only in the placebo group. Two weeks after withdrawal of enalapril, EDV and ESV increased to baseline levels but not to the higher levels observed with placebo. Conclusions. In patients with heart failure and reduced LVEF, chronic ACE inhibition with enalapril prevents progressive LV dilatation and systolic

Published
1992

11. Long-term Effects of Enalapril On Left-ventricular Diastolic Properties - Evidence for Reversed Remodeling

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - MD/MINT - Département de médecine interne, Pouleur, H., Melin, Jacques, Konstam, MA., van Eyll, Christian, Gallagher, P., Yusuf, S., Rousseau, MF., UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - MD/MINT - Département de médecine interne, Pouleur, H., Melin, Jacques, Konstam, MA., van Eyll, Christian, Gallagher, P., Yusuf, S., and Rousseau, MF.

Published
1992

18. Effects of the Beta-1-adrenergic Receptor Partial Agonist Xamoterol On Left-ventricular Diastolic Function - An Evaluation After 1-6 Years of Oral-therapy

Author

UCL, Pouleur, H., Etienne, Jacques, Van Mechelen, Henri, Gurné, Olivier, Rousseau, MF., CONF ON DIASTOLIC FUNCTION IN HEART FAILURE : CLINICAL APPROACHES TO ITS UNDERSTANDING AND TREATMENT, UCL, Pouleur, H., Etienne, Jacques, Van Mechelen, Henri, Gurné, Olivier, Rousseau, MF., and CONF ON DIASTOLIC FUNCTION IN HEART FAILURE : CLINICAL APPROACHES TO ITS UNDERSTANDING AND TREATMENT

Published
1990

21. Assessment of Left-ventricular Contractility From Late Systolic Stress-volume Relations

Author

UCL - MD/FSIO - Département de physiologie et pharmacologie, Pouleur, H., Rousseau, MF., van Eyll, Christian, Van Mechelen, Henri, Brasseur, LA., Charlier, AA., UCL - MD/FSIO - Département de physiologie et pharmacologie, Pouleur, H., Rousseau, MF., van Eyll, Christian, Van Mechelen, Henri, Brasseur, LA., and Charlier, AA.

Published
1982

24. Assessment of Tl-201 Redistribution Versus Glucose-utilization As Predictors of Viability After Coronary-occlusion and Reperfusion

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, Melin, Jacques, Wijns, W., Keyeux, André, Gurné, Olivier, Robert, Annie, Vincent, Marie-Françoise, Cogneau, M., Bol, Anne, Michel, Christian, Charlier, A.A., Pouleur, H., UCL - Cliniques universitaires Saint-Luc, UCL - MD/FSIO - Département de physiologie et pharmacologie, Melin, Jacques, Wijns, W., Keyeux, André, Gurné, Olivier, Robert, Annie, Vincent, Marie-Françoise, Cogneau, M., Bol, Anne, Michel, Christian, Charlier, A.A., and Pouleur, H.

Published
1986

39. Could Nifedipine Be Useful Before Surgery in Valvular Regurgitation

Author

UCL - MD/FSIO - Département de physiologie et pharmacologie, Rousseau, MF., Pouleur, H., van Eyll, Christian, Charlier, AA., Brasseur, LA., UCL - MD/FSIO - Département de physiologie et pharmacologie, Rousseau, MF., Pouleur, H., van Eyll, Christian, Charlier, AA., and Brasseur, LA.

Published
1982

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