1. Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.
- Author
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Piccirillo SG, Spiteri I, Sottoriva A, Touloumis A, Ber S, Price SJ, Heywood R, Francis NJ, Howarth KD, Collins VP, Venkitaraman AR, Curtis C, Marioni JC, Tavaré S, and Watts C
- Subjects
- Cell Line, Tumor, Drug Resistance, Neoplasm, Humans, Brain Neoplasms drug therapy, Brain Neoplasms pathology, Ependyma pathology, Glioblastoma drug therapy, Glioblastoma pathology, Neoplastic Stem Cells pathology, Neural Stem Cells pathology
- Abstract
Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance., (©2014 American Association for Cancer Research.)
- Published
- 2015
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