Search

Your search keyword '"Liu, Hanqiao"' showing total 6 results
Start Over Author "Liu, Hanqiao" Publisher american association for cancer research
6 results on '"Liu, Hanqiao"'

1. Abstract 856: Proteomic analysis of serum in workers exposed to diesel engine exhaust

Author

Rahman, Mohammad L., primary, Dai, Yufei, additional, Vermeulen, Roel, additional, Hu, Wei, additional, Bassig, Bryan, additional, Drizik, Eduard, additional, Corbett, Sean, additional, Ren, Dianzhi, additional, Duan, Huawei, additional, Niu, Yong, additional, Xu, Jun, additional, Fu, Wei, additional, Meliefste, Kees, additional, Zhou, Baosen, additional, Zhang, Xiaohui, additional, Yang, Jufang, additional, Liu, Hanqiao, additional, Ye, Meng, additional, Liu, Gang, additional, Jia, Xiaowei, additional, Meng, Tao, additional, Bin, Ping, additional, Spira, Avrum, additional, Lenburg, Marc E., additional, Silverman, Debra, additional, Rothman, Nathaniel, additional, Zheng, Yuxin, additional, and Lan, Qing, additional

Published
2021
Full Text
View/download PDF

2. Abstract 5002: Premalignant squamous cell lung carcinoma lesions have distinct molecular subtypes associated with histologic progression

Author

Beane, Jennifer E., primary, Mazzilli, Sarah, additional, Campbell, Joshua, additional, Moy, Christopher, additional, Schaffer, Michael, additional, Perdomo, Catalina, additional, Jenkins, David, additional, Liu, Gang, additional, Zhang, Sherry, additional, Liu, Hanqiao, additional, Vick, Jessica, additional, Johnson, Evan, additional, Platero, Suso, additional, Lenburg, Marc, additional, Reid, Mary, additional, Dhillon, Samjot S., additional, and Spira, Avrum, additional

Published
2017
Full Text
View/download PDF

4. Abstract 3077: Dysregulation of microRNA-mRNA regulatory networks in the bronchial airway epithelium of smokers with lung cancer

Author

Pavel, Ana Brandusa, primary, Campbell, Joshua D., additional, Liu, Gang, additional, Zhang, Sherry, additional, Liu, Hanqiao, additional, Luo, Lingqi, additional, Xiao, Ji, additional, Porta, Kate, additional, Whitney, Duncan, additional, Dubinett, Steven, additional, Elashoff, David, additional, Lenburg, Marc E., additional, and Spira, Avrum, additional

Published
2015
Full Text
View/download PDF

5. Abstract 1574: Leveraging bronchial airway gene expression to develop a nasal biomarker for lung cancer detection

Author

Perez-Rogers, Joseph, primary, Gerrein, Joseph, additional, Anderlind, Christina, additional, Xiao, Xiaohui, additional, Liu, Hanqiao, additional, Kusko, Rebecca, additional, Campbell, Joshua, additional, Wang, Teresa, additional, Alekseyev, Yuriy, additional, Liu, Gang, additional, Porta, Kate, additional, Whitney, Duncan, additional, Spira, Avrum, additional, and Lenburg, Marc, additional

Published
2015
Full Text
View/download PDF

6. Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial.

Author

Garland LL, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane JE, Wojtowicz M, and Chow HS

Subjects
Anti-Inflammatory Agents, Non-Steroidal pharmacology, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Gene Expression Profiling, Humans, Inflammation drug therapy, Inflammation epidemiology, Male, Middle Aged, Nasal Mucosa drug effects, Prognosis, Smoking drug therapy, Smoking epidemiology, Aspirin pharmacology, Biomarkers analysis, Gene Expression Regulation drug effects, Inflammation genetics, Nasal Mucosa metabolism, Smokers statistics & numerical data, Smoking genetics
Abstract

A chemopreventive effect of aspirin (ASA) on lung cancer risk is supported by epidemiologic and preclinical studies. We conducted a randomized, double-blinded study in current heavy smokers to compare modulating effects of intermittent versus continuous low-dose ASA on nasal epithelium gene expression and arachidonic acid (ARA) metabolism. Fifty-four participants were randomized to intermittent (ASA 81 mg daily for one week/placebo for one week) or continuous (ASA 81 mg daily) for 12 weeks. Low-dose ASA suppressed urinary prostaglandin E2 metabolite (PGEM; change of -4.55 ± 11.52 from baseline 15.44 ± 13.79 ng/mg creatinine for arms combined, P = 0.02), a surrogate of COX-mediated ARA metabolism, but had minimal effects on nasal gene expression of nasal or bronchial gene-expression signatures associated with smoking, lung cancer, and chronic obstructive pulmonary disease. Suppression of urinary PGEM correlated with favorable changes in a smoking-associated gene signature ( P < 0.01). Gene set enrichment analysis (GSEA) showed that ASA intervention led to 1,079 enriched gene sets from the Canonical Pathways within the Molecular Signatures Database. In conclusion, low-dose ASA had minimal effects on known carcinogenesis gene signatures in nasal epithelium of current smokers but results in wide-ranging genomic changes in the nasal epithelium, demonstrating utility of nasal brushings as a surrogate to measure gene-expression responses to chemoprevention. PGEM may serve as a marker for smoking-associated gene-expression changes and systemic inflammation. Future studies should focus on NSAIDs or agent combinations with broader inhibition of pro-inflammatory ARA metabolism to shift gene signatures in an anti-carcinogenic direction., (©2019 American Association for Cancer Research.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results