Search

Your search keyword '"C. M. Chang"' showing total 13 results
Start Over Author "C. M. Chang" Publisher american association for cancer research (aacr)
13 results on '"C. M. Chang"'

1. Supplementary Figure 2 from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Author

Roger R. Reddel, Tracy M. Bryan, Christian D. Toouli, Andy C-M. Chang, Axel A. Neumann, Hilda A. Pickett, Amanda S. Nouwens, Lily I. Huschtscha, and Ying Cao

Abstract

Supplementary Figure 2 from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Published
2023
Full Text
View/download PDF

2. Supplementary Figure 6 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 6235K, "Route-specific" analysis of metastases.

Published
2023
Full Text
View/download PDF

3. Supplementary Figure 3 from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Author

Roger R. Reddel, Tracy M. Bryan, Christian D. Toouli, Andy C-M. Chang, Axel A. Neumann, Hilda A. Pickett, Amanda S. Nouwens, Lily I. Huschtscha, and Ying Cao

Abstract

Supplementary Figure 3 from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Published
2023
Full Text
View/download PDF

4. Supplementary Figure 7 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 6319K, Relationship between size of primary tumor and intravasation. Analyses of lymphatic vessel, cancer stem cell and macrophage density in primary tumors.

Published
2023
Full Text
View/download PDF

5. Supplementary Figure 1 from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Author

Roger R. Reddel, Tracy M. Bryan, Christian D. Toouli, Andy C-M. Chang, Axel A. Neumann, Hilda A. Pickett, Amanda S. Nouwens, Lily I. Huschtscha, and Ying Cao

Abstract

Supplementary Figure 1 from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Published
2023
Full Text
View/download PDF

6. Supplementary Figure 2 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 1263K, PDGF-dependent stimulation by MEFs of colon cancer cell invasion. STC1-dependent stimulation by fibroblasts of colon cancer cell migration.

Published
2023
Full Text
View/download PDF

7. Supplementary Figure 4 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 8870K, Histopathological analysis of primary tumors.

Published
2023
Full Text
View/download PDF

8. Supplementary Figure 1 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 2355K, Analyses of PDGF β-receptor expression in LIM1215 co-cultured with BJHTERT fibroblasts and PDGFβR ligand production of colon tumors cells. Basal migration levels and migration levels with co-cultured stimulated PDGF fibroblasts of colon cancer cell lines.

Published
2023
Full Text
View/download PDF

9. Supplementary Figure 3 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 1652K, Analysis of associations between STC1 expression and stroma abundance and survival.

Published
2023
Full Text
View/download PDF

10. Supplementary Methods and Figure Legend from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 144K

Published
2023
Full Text
View/download PDF

11. Supplementary Methods and Materials from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Author

Roger R. Reddel, Tracy M. Bryan, Christian D. Toouli, Andy C-M. Chang, Axel A. Neumann, Hilda A. Pickett, Amanda S. Nouwens, Lily I. Huschtscha, and Ying Cao

Abstract

Supplementary Methods and Materials from Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels

Published
2023
Full Text
View/download PDF

12. Supplementary Figure 5 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Arne Östman, Martin Augsten, Ramón Mangues, Roger R. Reddel, Andy C.-M. Chang, Tobias Sjöblom, Alberto Gallardo, Srinivas Veerla, Eleonor Olsson, Per Sandström, Karin Jirström, Linda Bojmar, Helgi Birgisson, Christina Hägglöf, Per-Henrik Edqvist, Artur Mezheyeuski, Sara Kiflemariam, Maja Bradic Lindh, María Virtudes Céspedes, and Cristina Peña

Abstract

PDF file - 938K, Analyses of relationship between size of primary tumor and metastases.

Published
2023
Full Text
View/download PDF

13. STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Author

Andy C.-M. Chang, Martin Augsten, Per Sandström, Srinivas Veerla, Linda Bojmar, Sara Kiflemariam, Arne Östman, Per-Henrik Edqvist, Karin Jirström, Helgi Birgisson, María Virtudes Céspedes, Christina Hägglöf, Roger R. Reddel, Alberto Gallardo, Ramon Mangues, Tobias Sjöblom, Cristina Peña, Eleonor Olsson, Maja Bradic Lindh, and Artur Mezheyeuski

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Stromal cell, medicine.medical_treatment, Transplantation, Heterologous, Metastasis, Mice, Cell Movement, Cell Line, Tumor, Animals, Humans, Medicine, Neoplasm Invasiveness, Receptors, Platelet-Derived Growth Factor, Receptor, Cells, Cultured, In Situ Hybridization, Glycoproteins, Oligonucleotide Array Sequence Analysis, Mice, Knockout, Platelet-Derived Growth Factor, biology, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Gene Expression Profiling, Growth factor, Cancer, Neoplasms, Experimental, Fibroblasts, HCT116 Cells, medicine.disease, Immunohistochemistry, Coculture Techniques, Transplantation, Oncology, biology.protein, Cancer research, Cancer-Associated Fibroblasts, RNA Interference, Colorectal Neoplasms, business, HT29 Cells, Platelet-derived growth factor receptor
Abstract

Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287–97. ©2012 AACR.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results