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Your search keyword '"Curnis, Flavio"' showing total 32 results
Start Over Author "Curnis, Flavio" Publisher american association for cancer research (aacr)
32 results on '"Curnis, Flavio"'

1. Abstract 2381: Gold nanorods functionalized with an alpha5beta1 ligand: a simple and robust nanosystem for early bladder cancer detection

Author

Alfano, Massimo, primary, Alchera, Elisa, additional, Sacchi, Angelina, additional, Gori, Alessandro, additional, Locatelli, Irene, additional, Gasparri, Anna Maria, additional, Colombo, Barbara, additional, Anderluzzi, Giulia, additional, Armanetti, Paolo, additional, Minichetti, Luca, additional, Salonia, Andrea, additional, Corti, Angelo, additional, and Curnis, Flavio, additional

Published
2023
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2. Supplementary Figure S4 from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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3. Supplementary Figure Legends from Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Author

Bianco, Mimma, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Curnis, Flavio, primary, Girlanda, Stefania, primary, Ponzoni, Maurilio, primary, Bertilaccio, Maria Teresa Sabrina, primary, Calcinotto, Arianna, primary, Sacchi, Angelina, primary, Ferrero, Elisabetta, primary, Ferrarini, Marina, primary, Chesi, Marta, primary, Bergsagel, P. Leif, primary, Bellone, Matteo, primary, Tonon, Giovanni, primary, Ciceri, Fabio, primary, Marcatti, Magda, primary, Caligaris-Cappio, Federico, primary, and Corti, Angelo, primary

Published
2023
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4. Supplementary Table S1 from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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5. Data from Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Author

Bianco, Mimma, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Curnis, Flavio, primary, Girlanda, Stefania, primary, Ponzoni, Maurilio, primary, Bertilaccio, Maria Teresa Sabrina, primary, Calcinotto, Arianna, primary, Sacchi, Angelina, primary, Ferrero, Elisabetta, primary, Ferrarini, Marina, primary, Chesi, Marta, primary, Bergsagel, P. Leif, primary, Bellone, Matteo, primary, Tonon, Giovanni, primary, Ciceri, Fabio, primary, Marcatti, Magda, primary, Caligaris-Cappio, Federico, primary, and Corti, Angelo, primary

Published
2023
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6. Supplementary figure and legend from Spatiotemporal Regulation of Tumor Angiogenesis by Circulating Chromogranin A Cleavage and Neuropilin-1 Engagement

Author

Dallatomasina, Alice, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Sacchi, Angelina, primary, Bianco, Mimma, primary, Daniele, Tiziana, primary, Esposito, Antonio, primary, Pastorino, Fabio, primary, Ponzoni, Mirco, primary, Marcucci, Fabrizio, primary, Curnis, Flavio, primary, and Corti, Angelo, primary

Published
2023
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7. Supplementary Table and Figure Legends from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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8. Data from Spatiotemporal Regulation of Tumor Angiogenesis by Circulating Chromogranin A Cleavage and Neuropilin-1 Engagement

Author

Dallatomasina, Alice, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Sacchi, Angelina, primary, Bianco, Mimma, primary, Daniele, Tiziana, primary, Esposito, Antonio, primary, Pastorino, Fabio, primary, Ponzoni, Mirco, primary, Marcucci, Fabrizio, primary, Curnis, Flavio, primary, and Corti, Angelo, primary

Published
2023
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10. Supplementary Figures S1-S5 from Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Author

Bianco, Mimma, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Curnis, Flavio, primary, Girlanda, Stefania, primary, Ponzoni, Maurilio, primary, Bertilaccio, Maria Teresa Sabrina, primary, Calcinotto, Arianna, primary, Sacchi, Angelina, primary, Ferrero, Elisabetta, primary, Ferrarini, Marina, primary, Chesi, Marta, primary, Bergsagel, P. Leif, primary, Bellone, Matteo, primary, Tonon, Giovanni, primary, Ciceri, Fabio, primary, Marcatti, Magda, primary, Caligaris-Cappio, Federico, primary, and Corti, Angelo, primary

Published
2023
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11. Supplementary Methods and References. from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
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12. Supplementary Tables S1-S4 from Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Author

Bianco, Mimma, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Curnis, Flavio, primary, Girlanda, Stefania, primary, Ponzoni, Maurilio, primary, Bertilaccio, Maria Teresa Sabrina, primary, Calcinotto, Arianna, primary, Sacchi, Angelina, primary, Ferrero, Elisabetta, primary, Ferrarini, Marina, primary, Chesi, Marta, primary, Bergsagel, P. Leif, primary, Bellone, Matteo, primary, Tonon, Giovanni, primary, Ciceri, Fabio, primary, Marcatti, Magda, primary, Caligaris-Cappio, Federico, primary, and Corti, Angelo, primary

Published
2023
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13. Supplementary Methods from Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Author

Bianco, Mimma, primary, Gasparri, Anna Maria, primary, Colombo, Barbara, primary, Curnis, Flavio, primary, Girlanda, Stefania, primary, Ponzoni, Maurilio, primary, Bertilaccio, Maria Teresa Sabrina, primary, Calcinotto, Arianna, primary, Sacchi, Angelina, primary, Ferrero, Elisabetta, primary, Ferrarini, Marina, primary, Chesi, Marta, primary, Bergsagel, P. Leif, primary, Bellone, Matteo, primary, Tonon, Giovanni, primary, Ciceri, Fabio, primary, Marcatti, Magda, primary, Caligaris-Cappio, Federico, primary, and Corti, Angelo, primary

Published
2023
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16. Spatiotemporal Regulation of Tumor Angiogenesis by Circulating Chromogranin A Cleavage and Neuropilin-1 Engagement

Author

Dallatomasina, Alice, primary, Gasparri, Anna Maria, additional, Colombo, Barbara, additional, Sacchi, Angelina, additional, Bianco, Mimma, additional, Daniele, Tiziana, additional, Esposito, Antonio, additional, Pastorino, Fabio, additional, Ponzoni, Mirco, additional, Marcucci, Fabrizio, additional, Curnis, Flavio, additional, and Corti, Angelo, additional

Published
2019
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18. T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, additional, Basso, Veronica, additional, Petrozziello, Elisabetta, additional, Hess Michelini, Rodrigo, additional, Riba, Michela, additional, Freschi, Massimo, additional, Elia, Angela R., additional, Grioni, Matteo, additional, Curnis, Flavio, additional, Protti, Maria Pia, additional, Schumacher, Ton N., additional, Debets, Reno, additional, Swartz, Melody A., additional, Corti, Angelo, additional, Bellone, Matteo, additional, and Mondino, Anna, additional

Published
2017
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19. Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Author

Bianco, Mimma, primary, Gasparri, Anna Maria, additional, Colombo, Barbara, additional, Curnis, Flavio, additional, Girlanda, Stefania, additional, Ponzoni, Maurilio, additional, Bertilaccio, Maria Teresa Sabrina, additional, Calcinotto, Arianna, additional, Sacchi, Angelina, additional, Ferrero, Elisabetta, additional, Ferrarini, Marina, additional, Chesi, Marta, additional, Bergsagel, P. Leif, additional, Bellone, Matteo, additional, Tonon, Giovanni, additional, Ciceri, Fabio, additional, Marcatti, Magda, additional, Caligaris-Cappio, Federico, additional, and Corti, Angelo, additional

Published
2016
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20. Abstract 1778: Characterization and anti-tumor functionality of a neuroblastoma-specific peptide, either free or conjugated to nanocarriers

Author

Bartolini, Alice, primary, Loi, Monica, additional, Paolo, Daniela D., additional, Emionite, Laura, additional, Sacchi, Angelina, additional, Curnis, Flavio, additional, Bottoni, Gianluca, additional, Massollo, Michela, additional, Gagliani, Cristina, additional, Bruno, Silvia, additional, Gori, Alessandro, additional, Longhi, Renato, additional, Cilli, Michele, additional, Tacchetti, Carlo, additional, Corti, Angelo, additional, Sambuceti, Gianmario, additional, Ponzoni, Mirco, additional, Marchiò, Serena, additional, and Pastorino, Fabio, additional

Published
2014
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32. T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Maria Pia Protti, Tabea Sturmheit, Angelo Corti, Massimo Freschi, Matteo Bellone, Ton N. Schumacher, Matteo Grioni, Rodrigo Hess Michelini, Anna Mondino, Michela Riba, Elisabetta Petrozziello, Melody A. Swartz, Angela Elia, Veronica Basso, Reno Debets, Teresa Manzo, Flavio Curnis, Publica, Manzo, Teresa, Sturmheit, Tabea, Basso, Veronica, Petrozziello, Elisabetta, Michelini, Rodrigo He, Riba, Michela, Freschi, Massimo, Elia, Angela R., Grioni, Matteo, Curnis, Flavio, Protti, Maria Pia, Schumacher, Ton N., Debets, Reno, Swartz, Melody A., Corti, Angelo, Bellone, Matteo, Mondino, Anna, and Medical Oncology

Subjects
Male, 0301 basic medicine, Cancer Research, medicine.medical_treatment, Fluorescent Antibody Technique, Adenocarcinoma, CD8-Positive T-Lymphocytes, Biology, Real-Time Polymerase Chain Reaction, Immunotherapy, Adoptive, Minor Histocompatibility Antigens, Cell therapy, Mice, 03 medical and health sciences, Antigen, EMB, medicine, Minor histocompatibility antigen, Animals, Tumor Necrosis Factor-alpha, Gene Expression Profiling, T-cell receptor, Prostatic Neoplasms, Immunotherapy, Flow Cytometry, Immunohistochemistry, Histocompatibility, Mice, Inbred C57BL, Tumor Debulking, 030104 developmental biology, Oncology, Immunology, Tumor necrosis factor alpha
Abstract

Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such effects could be reproduced in autologous settings by TCR gene–engineered lymphocytes. We report that T cells redirected either to a broadly expressed Y-encoded minor H antigen or to a tumor-associated antigen, although poorly effective if individually transferred, when simultaneously administered enabled acute autochthonous tumor debulking and resulted in durable clinical remission. Y-redirected T cells proved hyporesponsive in peripheral lymphoid organs, whereas they retained effector function at the tumor site, where in synergy with tumor-redirected lymphocytes, they instructed TNFα expression, endothelial cell activation, and intratumoral T-cell infiltration. While neutralizing TNFα hindered GVT effects by the combined T-cell infusion, a single injection of picogram amounts of NGR-TNF, a tumor vessel–targeted TNFα derivative currently in phase III clinical trials, substituted for Y-redirected cells and enabled tumor debulking by tumor-redirected lymphocytes. Together, our results provide new mechanistic insights into allogeneic GVT, validate the importance of targeting the tumor and its associated stroma, and prove the potency of a novel combined approach suitable for immediate clinical implementation. Cancer Res; 77(3); 658–71. ©2016 AACR.

Published
2017

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