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Your search keyword '"Gabriella Marfè"' showing total 11 results
Start Over Author "Gabriella Marfè" Publisher american association for cancer research (aacr)
11 results on '"Gabriella Marfè"'

1. Supplementary Table 1 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 427K, Effects of the combination cetuximab plus fingolimod on tumor growth of mice xenografted with GEO-CR resistant tumors

Published
2023
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2. Supplementary Figure 5 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 5320K, Validation of antibodies for analysis of SphK1 expression on FFPE colorectal cancer tissues

Published
2023
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3. Supplementary Figure 3 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 503K, Effects of SphK1 modulation on cetuximab sensitivity in resistant colorectal cancer cell lines

Published
2023
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4. Supplementary Figure 4 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 1047K, Effects of the combination cetuximab plus fingolimod on apoptosis of GEO-CR tumor xenografts

Published
2023
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5. Supplementary Figure 6 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 2068K, Correlation of SphK1 expression with clinical data in colorectal cancer patients

Published
2023
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6. Supplementary Methods from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 39K

Published
2023
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7. Supplementary Figure Legend from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 32K

Published
2023
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8. Supplementary Figure 2 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 483K, Effects of SphK1 inhibition by DMS on cetuximab sensitivity in resistant colorectal cancer cell lines

Published
2023
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9. Supplementary Figure 1 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 357K, Sensitivity to cetuximab of a panel of human colorectal cancer cell lines

Published
2023
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10. Data from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

Purpose: Although the anti–EGF receptor (EGFR) monoclonal antibody cetuximab is an effective strategy in colorectal cancer therapy, its clinical use is limited by intrinsic or acquired resistance. Alterations in the “sphingolipid rheostat”—the balance between the proapoptotic molecule ceramide and the mitogenic factor sphingosine-1-phosphate (S1P)—due to sphingosine kinase 1 (SphK1) overactivation have been involved in resistance to anticancer-targeted agents. Moreover, cross-talks between SphK1 and EGFR-dependent signaling pathways have been described.Experimental design: We investigated SphK1 contribution to cetuximab resistance in colorectal cancer, in preclinical in vitro/in vivo models, and in tumor specimens from patients.Results: SphK1 was found overexpressed and overactivated in colorectal cancer cells with intrinsic or acquired resistance to cetuximab. SphK1 contribution to resistance was supported by the demonstration that SphK1 inhibition by N,N-dimethyl-sphingosine or silencing via siRNA in resistant cells restores sensitivity to cetuximab, whereas exogenous SphK1 overexpression in sensitive cells confers resistance to these agents. Moreover, treatment of resistant cells with fingolimod (FTY720), a S1P receptor (S1PR) antagonist, resulted in resensitization to cetuximab both in vitro and in vivo, with inhibition of tumor growth, interference with signal transduction, induction of cancer cells apoptosis, and prolongation of mice survival. Finally, a correlation between SphK1 expression and cetuximab response was found in colorectal cancer patients. Clin Cancer Res; 19(1); 138–47. ©2012 AACR.

Published
2023
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11. Supplementary Table 2 from Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Author

Roberto Bianco, Sabino De Placido, Giancarlo Troncone, Bianca Maria Veneziani, Chiara Carlomagno, Alfonso De Stefano, Adelaide Greco, Antonella Zannetti, Silvana Del Vecchio, Gabriella Marfè, Vincenzo Damiano, Valentina D'Amato, Claudia D'Amato, Lucia Nappi, Luigi Formisano, Umberto Malapelle, Roberta Marciano, and Roberta Rosa

Abstract

PDF file - 908K, Multivariate analysis correlating the response to cetuximab-based regimens to different factors

Published
2023
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