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Your search keyword '"J Pfau"' showing total 9 results
Start Over Author "J Pfau" Publisher american association for cancer research (aacr)
9 results on '"J Pfau"'

7. Data from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

Author

Angelika Amon, Michael T. Hemann, Clary B. Clish, Lan Wang, Tao Huang, Na Zhong, Sarah J. Pfau, Marianna Trakala, Stefano Santaguida, Amy Deik, Kevin Bullock, Peter M. Bruno, Kaiying Wang, Hui Yuwen, and Yun-Chi Tang

Abstract

Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify small molecules that could selectively kill aneuploid cells, we identified the compound N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide monohydrochloride (DL-PDMP), an antagonist of UDP-glucose ceramide glucosyltransferase. DL-PDMP selectively inhibited proliferation of aneuploid primary mouse embryonic fibroblasts and aneuploid colorectal cancer cells. Its selective cytotoxic effects were based on further accentuating the elevated levels of ceramide, which characterize aneuploid cells, leading to increased apoptosis. We observed that DL-PDMP could also enhance the cytotoxic effects of paclitaxel, a standard-of-care chemotherapeutic agent that causes aneuploidy, in human colon cancer and mouse lymphoma cells. Our results offer pharmacologic evidence that the aneuploid state in cancer cells can be targeted selectively for therapeutic purposes, or for reducing the toxicity of taxane-based drug regimens. Cancer Res; 77(19); 5272–86. ©2017 AACR.

Published
2023
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9. Table S1 to S3 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

Author

Angelika Amon, Michael T. Hemann, Clary B. Clish, Lan Wang, Tao Huang, Na Zhong, Sarah J. Pfau, Marianna Trakala, Stefano Santaguida, Amy Deik, Kevin Bullock, Peter M. Bruno, Kaiying Wang, Hui Yuwen, and Yun-Chi Tang

Abstract

Table S1: Summary of compound effect in aneuploid Ts13 MEF compared to euploid wild-type MEF. Table S2: shRNA and siRNA sequences used in this study. Table S3: Primers used for quantitative Real-Time PCR.

Published
2023
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