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Start Over Author "Kangarlu A" Publisher american association for cancer research (aacr)
19 results on '"Kangarlu A"'

8. Supplementary Figure Legends 1-6 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Lopez, Kim A., primary, Tannenbaum, Aaron M., primary, Assanah, Marcela C., primary, Linskey, Katy, primary, Yun, Jonathan, primary, Kangarlu, Alayar, primary, Gil, Orlando D., primary, Canoll, Peter, primary, and Bruce, Jeffrey N., primary

Published
2023
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10. Supplementary Figure 5 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure 5 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

11. Supplementary Figure 2 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure 2 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

12. Supplementary Figure 6 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure 6 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

13. Supplementary Figure 3 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure 3 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

14. Supplementary Methods from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Methods from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

15. Supplementary Figure 1 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure 1 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

16. Supplementary Figure Legends 1-6 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure Legends 1-6 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

17. Supplementary Figure 4 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Jeffrey N. Bruce, Peter Canoll, Orlando D. Gil, Alayar Kangarlu, Jonathan Yun, Katy Linskey, Marcela C. Assanah, Aaron M. Tannenbaum, and Kim A. Lopez

Abstract

Supplementary Figure 4 from Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Published
2023

18. Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors

Author

Peter Canoll, Katy Linskey, Marcela Assanah, Kim A. Lopez, Jeffrey N. Bruce, Alayar Kangarlu, Orlando Gil, Aaron M. Tannenbaum, and Jonathan Yun

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Platelet-derived growth factor, Cell Survival, Biology, Article, chemistry.chemical_compound, medicine, Animals, Progenitor cell, Progenitor, Platelet-Derived Growth Factor, Brain Neoplasms, Immunohistochemistry, Xenograft Model Antitumor Assays, Rats, Disease Models, Animal, medicine.anatomical_structure, Oncology, chemistry, Neoplastic Stem Cells, biology.protein, Neuroglia, Topotecan, Stem cell, Glioblastoma, Platelet-derived growth factor receptor, medicine.drug
Abstract

The contribution of microenvironment to tumor growth has important implications for optimizing chemotherapeutic response and understanding the biology of recurrent tumors. In this study, we tested the effects of locally administered topotecan on a rat model of glioblastoma that is induced by intracerebral injection of PDGF (platelet-derived growth factor)-IRES (internal ribosome entry site)-GFP (green fluorescent protein)–expressing retrovirus, treated the tumors by convection-enhanced delivery (CED) of topotecan (136 μmol/L) for 1, 4, or 7 days, and then characterized the effects on both the retrovirus-transformed tumor cells (GFP+ cells) as well as the uninfected glial progenitor cells (GFP− cells) that are recruited to the tumor. Topotecan treatment reduced GFP+ cells about 10-fold and recruited progenitors by about 80-fold while providing a significant survival advantage that improved with greater treatment duration. Regions of glial progenitor ablation occurred corresponding to the anatomic distribution of topotecan as predicted by MRI of a surrogate tracer. Histopathologic changes in recurrent tumors point to a decrease in recruitment, most likely due to the chemotherapeutic ablation of the recruitable progenitor pool. Cancer Res; 71(11); 3963–71. ©2011 AACR.

Published
2011

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