Search

Your search keyword '"Makoto Yamagishi"' showing total 7 results
Start Over Author "Makoto Yamagishi" Publisher american association for cancer research (aacr)
7 results on '"Makoto Yamagishi"'

1. Supplementary Figure 1 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma

Author

Kaoru Uchimaru, Toshiki Watanabe, Arinobu Tojo, Nobukazu Watanabe, Tadanori Yamochi, Makoto Yamagishi, Satomi Asanuma, Naoki Oyaizu, Koichiro Yuji, Nobuhiro Ohno, Tomohiro Ishigaki, Eri Watanabe, Kazumi Nakano, and Seiichiro Kobayashi

Abstract

PDF file - 51KB, Representative flow cytometric analysis of a patient with smoldering-type ATL (patient no. 12).

Published
2023

2. Supplementary Table 1 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma

Author

Kaoru Uchimaru, Toshiki Watanabe, Arinobu Tojo, Nobukazu Watanabe, Tadanori Yamochi, Makoto Yamagishi, Satomi Asanuma, Naoki Oyaizu, Koichiro Yuji, Nobuhiro Ohno, Tomohiro Ishigaki, Eri Watanabe, Kazumi Nakano, and Seiichiro Kobayashi

Abstract

XLSX file - 47KB, Clinical profile and flow cytometry data of patients with HTLV-1 infection and normal controls.

Published
2023

3. Data from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma

Author

Kaoru Uchimaru, Toshiki Watanabe, Arinobu Tojo, Nobukazu Watanabe, Tadanori Yamochi, Makoto Yamagishi, Satomi Asanuma, Naoki Oyaizu, Koichiro Yuji, Nobuhiro Ohno, Tomohiro Ishigaki, Eri Watanabe, Kazumi Nakano, and Seiichiro Kobayashi

Abstract

Purpose: Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene, has recently been reported to be ectopically expressed in primary adult T-cell leukemia–lymphoma (ATL) cells. We incorporated CADM1 into flow-cytometric analysis to reveal oncogenic mechanisms in human T-cell lymphotrophic virus type I (HTLV-I) infection by purifying cells from the intermediate stages of ATL development.Experimental Design: We isolated CADM1- and CD7-expressing peripheral blood mononuclear cells of asymptomatic carriers and ATLs using multicolor flow cytometry. Fluorescence-activated cell sorted (FACS) subpopulations were subjected to clonal expansion and gene expression analysis.Results: HTLV-I–infected cells were efficiently enriched in CADM1+ subpopulations (D, CADM1posCD7dim and N, CADM1posCD7neg). Clonally expanding cells were detected exclusively in these subpopulations in asymptomatic carriers with high proviral load, suggesting that the appearance of D and N could be a surrogate marker of progression from asymptomatic carrier to early ATL. Further disease progression was accompanied by an increase in N with a reciprocal decrease in D, indicating clonal evolution from D to N. The gene expression profiles of D and N in asymptomatic carriers showed similarities to those of indolent ATLs, suggesting that these subpopulations represent premalignant cells. This is further supported by the molecular hallmarks of ATL, that is, drastic downregulation of miR-31 and upregulation of abnormal Helios transcripts.Conclusion: The CADM1 versus CD7 plot accurately reflects disease progression in HTLV-I infection, and CADM1+ cells with downregulated CD7 in asymptomatic carriers have common properties with those in indolent ATLs. Clin Cancer Res; 20(11); 2851–61. ©2014 AACR.

Published
2023

5. Supplementary Figure 3 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma

Author

Kaoru Uchimaru, Toshiki Watanabe, Arinobu Tojo, Nobukazu Watanabe, Tadanori Yamochi, Makoto Yamagishi, Satomi Asanuma, Naoki Oyaizu, Koichiro Yuji, Nobuhiro Ohno, Tomohiro Ishigaki, Eri Watanabe, Kazumi Nakano, and Seiichiro Kobayashi

Abstract

PDF file - 29KB, Proportion of each subpopulation in the CADM1 vs. CD7 plot in normal controls.

Published
2023

6. Supplementary Figure 4 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma

Author

Kaoru Uchimaru, Toshiki Watanabe, Arinobu Tojo, Nobukazu Watanabe, Tadanori Yamochi, Makoto Yamagishi, Satomi Asanuma, Naoki Oyaizu, Koichiro Yuji, Nobuhiro Ohno, Tomohiro Ishigaki, Eri Watanabe, Kazumi Nakano, and Seiichiro Kobayashi

Abstract

PDF file - 41KB, Temporal changes in the data of a chronic-type ATL patient.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results