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Start Over Author "Maria Dasovich" Publisher american association for cancer research (aacr)
8 results on '"Maria Dasovich"'

1. Table S1 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

Phenotype of T-cells used in Xenograft Studies

Published
2023
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2. Table S4 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

Summary of MOR209/ES414 and scFv-scFv Effect on Survival of Mice from C4-2B Xenograft Study

Published
2023
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3. Figure S3 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

Serum levels of human PSA from day 56 of the MDA-PCa-2b xenograft study (as shown in Figures 5C, 5D).

Published
2023
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4. Supplementary Methods from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

Supplementary Methods and Supplementary Figure Legends

Published
2023
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5. Figure S1 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

A. Binding of MOR209/ES414 or human IgG1 control on representative CHO cell lines expressing different Fcγ receptors monitored by flow cytometry and plotted as median fluorescence intensity (MFI). B. Cell divisions observed in proliferating CD4+ and CD8+ T cells induced by MOR209/ES414 (0, 1, 10 nM) in the presence of target (C4-2B cells) visualized by loss of CFSE fluorescence. C. T-cell proliferation induced by 1 nM MOR209/ES414 in the presence of C4-2B cells with the number of cell divisions (0-7) indicated.

Published
2023
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6. Table S2 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

Estimated PSMA Receptor Densities and Relative Potency of MOR209/ES414

Published
2023
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7. Figure S2 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

A. Relative cytokine release observed after \ 24 hours from T cells in the presence of bispecific molecules (5 nM) and C4-2B target cells. Data plotted is within the limit of detection of the assay. B, C. Activation and cytokine release induced by the anti-PSMA x I2C ADAPTIR control molecule. PBMC were stimulated for 20 hrs in the presence of serial dilutions of C4-2B with tandem scFv-scFv (scFv-scFv), the hybrid ADAPTIR molecule or MOR209/ES414 as described before. B. Activation was assessed by measuring the fraction of CD4+ or CD8+ T cells upregulating CD69. C. Cytokine secretion was measured in the culture supernatants. The graphs show levels of IL-2, and IFN-γ; similar trends were observed for TNFα, GM-CSF, IL-4, IL-5 IL-10, IL-13 and IL-17. The figure shows representative results obtained from two independent experiments, each including 2 different human PBMC donors.

Published
2023
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8. Table S3 from MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Author

John W. Blankenship, Jane A. Gross, Sateesh K. Natarajan, Catherine J. McMahan, David Bienvenue, Paul A. Algate, Jennifer Wiens, Padma Ravikumar, Robert E. Miller, John Kumer, Rebecca Gottschalk, Hang Fang, Maria Dasovich, Mollie Daugherty, Ruth A. Chenault, Jeannette Bannink, Robert Bader, Toddy Sewell, and Gabriela Hernandez-Hoyos

Abstract

Summary of Median Survival Statistics from C4-2B Xenograft Study

Published
2023
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