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Your search keyword '"Perez-Mancera, Pedro A."' showing total 27 results
Start Over Author "Perez-Mancera, Pedro A." Publisher american association for cancer research (aacr)
27 results on '"Perez-Mancera, Pedro A."'

1. Figure S7 from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Author

Humpton, Timothy J., primary, Alagesan, Brinda, primary, DeNicola, Gina M., primary, Lu, Dan, primary, Yordanov, Georgi N., primary, Leonhardt, Carl S., primary, Yao, Melissa A., primary, Alagesan, Priya, primary, Zaatari, Maya N., primary, Park, Youngkyu, primary, Skepper, Jeremy N., primary, Macleod, Kay F., primary, Perez-Mancera, Pedro A., primary, Murphy, Michael P., primary, Evan, Gerard I., primary, Vousden, Karen H., primary, and Tuveson, David A., primary

Published
2023
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2. Supplementary Table S12 from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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3. Supplementary Tables S14-S17 from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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4. Data from Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Author

Humpton, Timothy J., primary, Alagesan, Brinda, primary, DeNicola, Gina M., primary, Lu, Dan, primary, Yordanov, Georgi N., primary, Leonhardt, Carl S., primary, Yao, Melissa A., primary, Alagesan, Priya, primary, Zaatari, Maya N., primary, Park, Youngkyu, primary, Skepper, Jeremy N., primary, Macleod, Kay F., primary, Perez-Mancera, Pedro A., primary, Murphy, Michael P., primary, Evan, Gerard I., primary, Vousden, Karen H., primary, and Tuveson, David A., primary

Published
2023
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5. Data from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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6. Supplementary Figures S1-S18 from Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., primary, Lu, Jia, primary, Lin, Yi-Jang, primary, Strasser, Samantha Dale, primary, Paulo, Joao A., primary, Huang, Tannie Q., primary, Morales, Carolina, primary, Yan, Wei, primary, Cook, Joshua, primary, Nowak, Jonathan A., primary, Brubaker, Douglas K., primary, Joughin, Brian A., primary, Johnson, Christian W., primary, DeStefanis, Rebecca A., primary, Ghazi, Phaedra C., primary, Gondi, Sudershan, primary, Wales, Thomas E., primary, Iacob, Roxana E., primary, Bogdanova, Lana, primary, Gierut, Jessica J., primary, Li, Yina, primary, Engen, John R., primary, Perez-Mancera, Pedro A., primary, Braun, Benjamin S., primary, Gygi, Steven P., primary, Lauffenburger, Douglas A., primary, Westover, Kenneth D., primary, and Haigis, Kevin M., primary

Published
2023
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7. Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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8. Supplementary Table 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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9. Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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10. Data from Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

Author

Ireland, Lucy, primary, Santos, Almudena, primary, Ahmed, Muhammad S., primary, Rainer, Carolyn, primary, Nielsen, Sebastian R., primary, Quaranta, Valeria, primary, Weyer-Czernilofsky, Ulrike, primary, Engle, Danielle D., primary, Perez-Mancera, Pedro A., primary, Coupland, Sarah E., primary, Taktak, Azzam, primary, Bogenrieder, Thomas, primary, Tuveson, David A., primary, Campbell, Fiona, primary, Schmid, Michael C., primary, and Mielgo, Ainhoa, primary

Published
2023
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11. Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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12. Supplementary Figure Legends, Supplementary Tables 1 and 2 and Supplementary Materials and Methods from Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

Author

Ireland, Lucy, primary, Santos, Almudena, primary, Ahmed, Muhammad S., primary, Rainer, Carolyn, primary, Nielsen, Sebastian R., primary, Quaranta, Valeria, primary, Weyer-Czernilofsky, Ulrike, primary, Engle, Danielle D., primary, Perez-Mancera, Pedro A., primary, Coupland, Sarah E., primary, Taktak, Azzam, primary, Bogenrieder, Thomas, primary, Tuveson, David A., primary, Campbell, Fiona, primary, Schmid, Michael C., primary, and Mielgo, Ainhoa, primary

Published
2023
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13. Supplementary Figures 1 through 9 from Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

Author

Ireland, Lucy, primary, Santos, Almudena, primary, Ahmed, Muhammad S., primary, Rainer, Carolyn, primary, Nielsen, Sebastian R., primary, Quaranta, Valeria, primary, Weyer-Czernilofsky, Ulrike, primary, Engle, Danielle D., primary, Perez-Mancera, Pedro A., primary, Coupland, Sarah E., primary, Taktak, Azzam, primary, Bogenrieder, Thomas, primary, Tuveson, David A., primary, Campbell, Fiona, primary, Schmid, Michael C., primary, and Mielgo, Ainhoa, primary

Published
2023
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14. Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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15. Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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16. Supplementary Figure 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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17. Supplementary Figure 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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18. Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer

Author

Caligiuri, Giuseppina, primary, Thalappillil, Jennifer S., additional, Shakiba, Mojdeh, additional, Nadella, Sandeep, additional, Hinds, Juliene, additional, Courtois, Elise, additional, Flynn, William F., additional, Alagesan, Brinda, additional, Yordanov, Georgi N., additional, Kaminow, Benjamin, additional, Robson, Paul, additional, Perez-Mancera, Pedro A., additional, Preall, Jonathan, additional, Dobin, Alexander, additional, Park, Youngku, additional, and Tuveson, David A., additional

Published
2022
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19. Abstract 3647: Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer

Author

Thalappillil, Jennifer S., primary, Caligiuri, Giuseppina, additional, Nadella, Sandeep, additional, Alagesan, Brinda, additional, Yordanov, Georgi N., additional, Shakiba, Mojdeh, additional, Kaminow, Benjamin, additional, Hinds, Juliene, additional, Perez-Mancera, Pedro A., additional, Preall, Jonathan, additional, Dobin, Alexander, additional, Park, Youngkyu, additional, and Tuveson, David A., additional

Published
2022
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20. Tissue-Specific Oncogenic Activity of KRASA146T

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian Alan, Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A, Westover, Kenneth D., Haigis, Kevin M., Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian Alan, Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A, Westover, Kenneth D., and Haigis, Kevin M.

Abstract

KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS proteins. We used a cross-disciplinary approach to compare KRASG12D, a common mutant form, and KRASA146T, a mutant that occurs only in selected cancers. Biochemical and structural studies demonstrated that KRASA146T exhibits a marked extension of switch 1 away from the protein body and nucleotide binding site, which activates KRAS by promoting a high rate of intrinsic and guanine nucleotide exchange factor– induced nucleotide exchange. Using mice genetically engineered to express either allele, we found that KRASG12D and KRASA146T exhibit distinct tissue-specific effects on homeostasis that mirror mutational frequencies in human cancers. These tissue-specific phenotypes result from allele-specific signaling properties, demonstrating that context-dependent variations in signaling downstream of different KRAS mutants drive the KRAS mutational pattern seen in cancer. SIGNIFICANCE: Although epidemiologic and clinical studies have suggested allele-specific behaviors for KRAS, experimental evidence for allele-specific biological properties is limited. We combined structural biology, mass spectrometry, and mouse modeling to demonstrate that the selection for specific KRAS mutants in human cancers from different tissues is due to their distinct signaling properties., National Institutes of Health (Grant U01CA215798)

Published
2020

21. Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, additional, Lane, Brian, additional, Brumskill, Sarah, additional, Oldfield, Frances E., additional, Campbell, Fiona, additional, Andrews, Timothy, additional, Lu, Zipeng, additional, Perez-Mancera, Pedro A., additional, Liloglou, Triantafillos, additional, Ashworth, Milton, additional, Jalali, Mehdi, additional, Dawson, Rebecca, additional, Nunes, Quentin, additional, Phillips, Phoebe A., additional, Timms, John F., additional, Halloran, Christopher, additional, Greenhalf, William, additional, Neoptolemos, John P., additional, and Costello, Eithne, additional

Published
2020
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23. Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Author

Humpton, Timothy J., primary, Alagesan, Brinda, additional, DeNicola, Gina M., additional, Lu, Dan, additional, Yordanov, Georgi N., additional, Leonhardt, Carl S., additional, Yao, Melissa A., additional, Alagesan, Priya, additional, Zaatari, Maya N., additional, Park, Youngkyu, additional, Skepper, Jeremy N., additional, Macleod, Kay F., additional, Perez-Mancera, Pedro A., additional, Murphy, Michael P., additional, Evan, Gerard I., additional, Vousden, Karen H., additional, and Tuveson, David A., additional

Published
2019
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24. Tissue-Specific Oncogenic Activity of KRASA146T

Author

Poulin, Emily J., primary, Bera, Asim K., additional, Lu, Jia, additional, Lin, Yi-Jang, additional, Strasser, Samantha Dale, additional, Paulo, Joao A., additional, Huang, Tannie Q., additional, Morales, Carolina, additional, Yan, Wei, additional, Cook, Joshua, additional, Nowak, Jonathan A., additional, Brubaker, Douglas K., additional, Joughin, Brian A., additional, Johnson, Christian W., additional, DeStefanis, Rebecca A., additional, Ghazi, Phaedra C., additional, Gondi, Sudershan, additional, Wales, Thomas E., additional, Iacob, Roxana E., additional, Bogdanova, Lana, additional, Gierut, Jessica J., additional, Li, Yina, additional, Engen, John R., additional, Perez-Mancera, Pedro A., additional, Braun, Benjamin S., additional, Gygi, Steven P., additional, Lauffenburger, Douglas A., additional, Westover, Kenneth D., additional, and Haigis, Kevin M., additional

Published
2019
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25. Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

Author

Ireland, Lucy, primary, Santos, Almudena, additional, Ahmed, Muhammad S., additional, Rainer, Carolyn, additional, Nielsen, Sebastian R., additional, Quaranta, Valeria, additional, Weyer-Czernilofsky, Ulrike, additional, Engle, Danielle D., additional, Perez-Mancera, Pedro A., additional, Coupland, Sarah E., additional, Taktak, Azzam, additional, Bogenrieder, Thomas, additional, Tuveson, David A., additional, Campbell, Fiona, additional, Schmid, Michael C., additional, and Mielgo, Ainhoa, additional

Published
2016
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26. Abstract 798: Clonal analysis and clinical translation of pancreatic adenocarcinoma genomes.

Author

Barrett, Michael T., primary, Lenkiewicz, Elizabeth, additional, Lisa, Evers, additional, Perez-Mancera, Pedro, additional, Tuveson, David, additional, Aust, Daniela, additional, Pilarsky, Christian, additional, Aziz, Meraj, additional, Posner, Richard, additional, Ramanathan, Ramesh, additional, Velculescu, Victor, additional, Kramer, Amy, additional, Drebin, Jeffrey, additional, and Von Hoff, Daniel D., additional

Published
2013
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