Search

Your search keyword '"Resnick, Adam C."' showing total 28 results
Start Over Author "Resnick, Adam C." Publisher american association for cancer research (aacr)
28 results on '"Resnick, Adam C."'

1. Abstract 3566: Expansion of the Pediatric Brain Tumor Atlas: Children's Brain Tumor Network, Kids First Data Resource and Childhood Cancer Data Initiative Open Science effort

Author

Koptyra, Mateusz P., primary, Rahti, Komal, additional, Zhu, Yuankun, additional, Farrow, Bailey, additional, Miller, Daniel, additional, Kraya, Adam, additional, Guo, Yiran, additional, Madsen, Peter, additional, Van Kuren, Nicholas, additional, Huang, Xiaoyan, additional, Brown, Miguel A., additional, Mason, Jennifer L., additional, Kim, Meen Chul, additional, Heath, Allison P., additional, Ennis, Brian M., additional, Zhang, Bo, additional, Lilly, Jena V., additional, Rokita, Jo Lynne, additional, Friedman, Christopher, additional, Cuellar, Ximena P., additional, Sullivan, Catherine A., additional, Coleman, Noel, additional, Duros, Trang, additional, Nguyen, Thinh Q., additional, Drake, Emmett C., additional, Helili, Zeinab, additional, Frenkel, Beth A., additional, Trooskin, Gerri R., additional, Familiar, Ariana, additional, Viswanathan, Karthik, additional, Beck, Christopher M., additional, Hollawell, Madison L., additional, Baubet, Valerie P., additional, Kline, Cassie, additional, Santi, Mariarita, additional, Patton, Tatiana S., additional, Stefankiewicz, Stephanie, additional, Kamnaa, Arya, additional, Velasco, Ryan A., additional, Cardona, Dani, additional, Storm, Phillip J., additional, Resnick, Adam C., additional, and Network, o/b/o Children's Brain Tumor, additional

Published
2023
Full Text
View/download PDF

2. Abstract 6576: Gabriella Miller Kids First Data Resource Center (KFDRC): Empowering discovery across germline and somatic variation in pediatric cancer

Author

Higgins, David, primary, Thibert, Jean-Philippe, additional, Mattioni, Michele, additional, DiGiovanna, Jack, additional, Grossman, Robert L., additional, Farrow, Bailey K., additional, Wenger, Eric, additional, Volchenboum, Samuel, additional, Carroll, Robert J., additional, Haendel, Melissa A., additional, Taylor, Deanne M., additional, Zhu, Yuankun, additional, Ferretti, Vincent, additional, Resnick, Adam C., additional, and Heath, Allison P., additional

Published
2023
Full Text
View/download PDF

3. Supplementary File 1 from Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., primary, Kunz, Daniel J., primary, Johnston, Michael J., primary, Nikolic, Ana, primary, Narta, Kiran, primary, Zarrei, Mehdi, primary, King, Jennifer, primary, Ellestad, Katrina, primary, Dang, Ngoc Ha, primary, Cavalli, Florence M.G., primary, Kushida, Michelle M., primary, Coutinho, Fiona J., primary, Zhu, Yuankun, primary, Luu, Betty, primary, Ma, Yussanne, primary, Mungall, Andrew J., primary, Moore, Richard, primary, Marra, Marco A., primary, Taylor, Michael D., primary, Pugh, Trevor J., primary, Dirks, Peter B., primary, Strother, Douglas, primary, Lafay-Cousin, Lucie, primary, Resnick, Adam C., primary, Scherer, Stephen, primary, Senger, Donna L., primary, Simons, Benjamin D., primary, Chan, Jennifer A., primary, Morrissy, A. Sorana, primary, and Gallo, Marco, primary

Published
2023
Full Text
View/download PDF

4. Data from Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

Author

Pal, Sharmistha, primary, Kozono, David, primary, Yang, Xiaodong, primary, Fendler, Wojciech, primary, Fitts, Whitney, primary, Ni, Jing, primary, Alberta, John A., primary, Zhao, Jean, primary, Liu, Kevin X., primary, Bian, Jie, primary, Truffaux, Nathalene, primary, Weiss, William A., primary, Resnick, Adam C., primary, Bandopadhayay, Pratiti, primary, Ligon, Keith L., primary, DuBois, Steven G., primary, Mueller, Sabine, primary, Chowdhury, Dipanjan, primary, and Haas-Kogan, Daphne A., primary

Published
2023
Full Text
View/download PDF

5. SupSupplementary Figures and Tables from Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

Author

Pal, Sharmistha, primary, Kozono, David, primary, Yang, Xiaodong, primary, Fendler, Wojciech, primary, Fitts, Whitney, primary, Ni, Jing, primary, Alberta, John A., primary, Zhao, Jean, primary, Liu, Kevin X., primary, Bian, Jie, primary, Truffaux, Nathalene, primary, Weiss, William A., primary, Resnick, Adam C., primary, Bandopadhayay, Pratiti, primary, Ligon, Keith L., primary, DuBois, Steven G., primary, Mueller, Sabine, primary, Chowdhury, Dipanjan, primary, and Haas-Kogan, Daphne A., primary

Published
2023
Full Text
View/download PDF

6. Supplemental Table 1 from BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas

Author

Olow, Aleksandra, primary, Mueller, Sabine, primary, Yang, Xiaodong, primary, Hashizume, Rintaro, primary, Meyerowitz, Justin, primary, Weiss, William, primary, Resnick, Adam C., primary, Waanders, Angela J., primary, Stalpers, Lukas J.A., primary, Berger, Mitchel S., primary, Gupta, Nalin, primary, James, C. David, primary, Petritsch, Claudia K., primary, and Haas-Kogan, Daphne A., primary

Published
2023
Full Text
View/download PDF

7. Supplemental Figure 2 from BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas

Author

Olow, Aleksandra, primary, Mueller, Sabine, primary, Yang, Xiaodong, primary, Hashizume, Rintaro, primary, Meyerowitz, Justin, primary, Weiss, William, primary, Resnick, Adam C., primary, Waanders, Angela J., primary, Stalpers, Lukas J.A., primary, Berger, Mitchel S., primary, Gupta, Nalin, primary, James, C. David, primary, Petritsch, Claudia K., primary, and Haas-Kogan, Daphne A., primary

Published
2023
Full Text
View/download PDF

8. Supplementary File 2 from Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., primary, Kunz, Daniel J., primary, Johnston, Michael J., primary, Nikolic, Ana, primary, Narta, Kiran, primary, Zarrei, Mehdi, primary, King, Jennifer, primary, Ellestad, Katrina, primary, Dang, Ngoc Ha, primary, Cavalli, Florence M.G., primary, Kushida, Michelle M., primary, Coutinho, Fiona J., primary, Zhu, Yuankun, primary, Luu, Betty, primary, Ma, Yussanne, primary, Mungall, Andrew J., primary, Moore, Richard, primary, Marra, Marco A., primary, Taylor, Michael D., primary, Pugh, Trevor J., primary, Dirks, Peter B., primary, Strother, Douglas, primary, Lafay-Cousin, Lucie, primary, Resnick, Adam C., primary, Scherer, Stephen, primary, Senger, Donna L., primary, Simons, Benjamin D., primary, Chan, Jennifer A., primary, Morrissy, A. Sorana, primary, and Gallo, Marco, primary

Published
2023
Full Text
View/download PDF

9. Supplementary table 1 from Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

Author

Panditharatna, Eshini, primary, Kilburn, Lindsay B., primary, Aboian, Mariam S., primary, Kambhampati, Madhuri, primary, Gordish-Dressman, Heather, primary, Magge, Suresh N., primary, Gupta, Nalin, primary, Myseros, John S., primary, Hwang, Eugene I., primary, Kline, Cassie, primary, Crawford, John R., primary, Warren, Katherine E., primary, Cha, Soonmee, primary, Liang, Winnie S., primary, Berens, Michael E., primary, Packer, Roger J., primary, Resnick, Adam C., primary, Prados, Michael, primary, Mueller, Sabine, primary, and Nazarian, Javad, primary

Published
2023
Full Text
View/download PDF

10. Supplemental Figure 1 from BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas

Author

Olow, Aleksandra, primary, Mueller, Sabine, primary, Yang, Xiaodong, primary, Hashizume, Rintaro, primary, Meyerowitz, Justin, primary, Weiss, William, primary, Resnick, Adam C., primary, Waanders, Angela J., primary, Stalpers, Lukas J.A., primary, Berger, Mitchel S., primary, Gupta, Nalin, primary, James, C. David, primary, Petritsch, Claudia K., primary, and Haas-Kogan, Daphne A., primary

Published
2023
Full Text
View/download PDF

11. Supplementary Methods and Data from Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., primary, Kunz, Daniel J., primary, Johnston, Michael J., primary, Nikolic, Ana, primary, Narta, Kiran, primary, Zarrei, Mehdi, primary, King, Jennifer, primary, Ellestad, Katrina, primary, Dang, Ngoc Ha, primary, Cavalli, Florence M.G., primary, Kushida, Michelle M., primary, Coutinho, Fiona J., primary, Zhu, Yuankun, primary, Luu, Betty, primary, Ma, Yussanne, primary, Mungall, Andrew J., primary, Moore, Richard, primary, Marra, Marco A., primary, Taylor, Michael D., primary, Pugh, Trevor J., primary, Dirks, Peter B., primary, Strother, Douglas, primary, Lafay-Cousin, Lucie, primary, Resnick, Adam C., primary, Scherer, Stephen, primary, Senger, Donna L., primary, Simons, Benjamin D., primary, Chan, Jennifer A., primary, Morrissy, A. Sorana, primary, and Gallo, Marco, primary

Published
2023
Full Text
View/download PDF

12. Supplemental Data from Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

Author

Panditharatna, Eshini, primary, Kilburn, Lindsay B., primary, Aboian, Mariam S., primary, Kambhampati, Madhuri, primary, Gordish-Dressman, Heather, primary, Magge, Suresh N., primary, Gupta, Nalin, primary, Myseros, John S., primary, Hwang, Eugene I., primary, Kline, Cassie, primary, Crawford, John R., primary, Warren, Katherine E., primary, Cha, Soonmee, primary, Liang, Winnie S., primary, Berens, Michael E., primary, Packer, Roger J., primary, Resnick, Adam C., primary, Prados, Michael, primary, Mueller, Sabine, primary, and Nazarian, Javad, primary

Published
2023
Full Text
View/download PDF

13. Data from Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., primary, Kunz, Daniel J., primary, Johnston, Michael J., primary, Nikolic, Ana, primary, Narta, Kiran, primary, Zarrei, Mehdi, primary, King, Jennifer, primary, Ellestad, Katrina, primary, Dang, Ngoc Ha, primary, Cavalli, Florence M.G., primary, Kushida, Michelle M., primary, Coutinho, Fiona J., primary, Zhu, Yuankun, primary, Luu, Betty, primary, Ma, Yussanne, primary, Mungall, Andrew J., primary, Moore, Richard, primary, Marra, Marco A., primary, Taylor, Michael D., primary, Pugh, Trevor J., primary, Dirks, Peter B., primary, Strother, Douglas, primary, Lafay-Cousin, Lucie, primary, Resnick, Adam C., primary, Scherer, Stephen, primary, Senger, Donna L., primary, Simons, Benjamin D., primary, Chan, Jennifer A., primary, Morrissy, A. Sorana, primary, and Gallo, Marco, primary

Published
2023
Full Text
View/download PDF

14. Supplementary table 4 from Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

Author

Panditharatna, Eshini, primary, Kilburn, Lindsay B., primary, Aboian, Mariam S., primary, Kambhampati, Madhuri, primary, Gordish-Dressman, Heather, primary, Magge, Suresh N., primary, Gupta, Nalin, primary, Myseros, John S., primary, Hwang, Eugene I., primary, Kline, Cassie, primary, Crawford, John R., primary, Warren, Katherine E., primary, Cha, Soonmee, primary, Liang, Winnie S., primary, Berens, Michael E., primary, Packer, Roger J., primary, Resnick, Adam C., primary, Prados, Michael, primary, Mueller, Sabine, primary, and Nazarian, Javad, primary

Published
2023
Full Text
View/download PDF

15. Supplementary File 3 from Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., primary, Kunz, Daniel J., primary, Johnston, Michael J., primary, Nikolic, Ana, primary, Narta, Kiran, primary, Zarrei, Mehdi, primary, King, Jennifer, primary, Ellestad, Katrina, primary, Dang, Ngoc Ha, primary, Cavalli, Florence M.G., primary, Kushida, Michelle M., primary, Coutinho, Fiona J., primary, Zhu, Yuankun, primary, Luu, Betty, primary, Ma, Yussanne, primary, Mungall, Andrew J., primary, Moore, Richard, primary, Marra, Marco A., primary, Taylor, Michael D., primary, Pugh, Trevor J., primary, Dirks, Peter B., primary, Strother, Douglas, primary, Lafay-Cousin, Lucie, primary, Resnick, Adam C., primary, Scherer, Stephen, primary, Senger, Donna L., primary, Simons, Benjamin D., primary, Chan, Jennifer A., primary, Morrissy, A. Sorana, primary, and Gallo, Marco, primary

Published
2023
Full Text
View/download PDF

16. Supplementary table 2 from Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

Author

Panditharatna, Eshini, primary, Kilburn, Lindsay B., primary, Aboian, Mariam S., primary, Kambhampati, Madhuri, primary, Gordish-Dressman, Heather, primary, Magge, Suresh N., primary, Gupta, Nalin, primary, Myseros, John S., primary, Hwang, Eugene I., primary, Kline, Cassie, primary, Crawford, John R., primary, Warren, Katherine E., primary, Cha, Soonmee, primary, Liang, Winnie S., primary, Berens, Michael E., primary, Packer, Roger J., primary, Resnick, Adam C., primary, Prados, Michael, primary, Mueller, Sabine, primary, and Nazarian, Javad, primary

Published
2023
Full Text
View/download PDF

18. Abstract 632: Novel BRAF gene fusions in pediatric histiocytic neoplasms respond differentially to RAF targeted therapies based on dimerization profiles

Author

Jain, Payal, primary, Surrey, Lea F., additional, Straka, Joshua, additional, Russo, Pierre, additional, Womer, Richard, additional, Li, Marilyn, additional, Storm, Phillip B., additional, Waanders, Angela J., additional, Hogarty, Michael, additional, Picarsic, Jennifer, additional, and Resnick, Adam C., additional

Published
2020
Full Text
View/download PDF

19. Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., additional, Kunz, Daniel J., additional, Johnston, Michael J., additional, Nikolic, Ana, additional, Narta, Kiran, additional, Zarrei, Mehdi, additional, King, Jennifer, additional, Ellestad, Katrina, additional, Dang, Ngoc Ha, additional, Cavalli, Florence M.G., additional, Kushida, Michelle M., additional, Coutinho, Fiona J., additional, Zhu, Yuankun, additional, Luu, Betty, additional, Ma, Yussanne, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Marra, Marco A., additional, Taylor, Michael D., additional, Pugh, Trevor J., additional, Dirks, Peter B., additional, Strother, Douglas, additional, Lafay-Cousin, Lucie, additional, Resnick, Adam C., additional, Scherer, Stephen, additional, Senger, Donna L., additional, Simons, Benjamin D., additional, Chan, Jennifer A., additional, Morrissy, A. Sorana, additional, and Gallo, Marco, additional

Published
2019
Full Text
View/download PDF

20. Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

Author

Panditharatna, Eshini, primary, Kilburn, Lindsay B., additional, Aboian, Mariam S., additional, Kambhampati, Madhuri, additional, Gordish-Dressman, Heather, additional, Magge, Suresh N., additional, Gupta, Nalin, additional, Myseros, John S., additional, Hwang, Eugene I., additional, Kline, Cassie, additional, Crawford, John R., additional, Warren, Katherine E., additional, Cha, Soonmee, additional, Liang, Winnie S., additional, Berens, Michael E., additional, Packer, Roger J., additional, Resnick, Adam C., additional, Prados, Michael, additional, Mueller, Sabine, additional, and Nazarian, Javad, additional

Published
2018
Full Text
View/download PDF

21. Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

Author

Pal, Sharmistha, primary, Kozono, David, additional, Yang, Xiaodong, additional, Fendler, Wojciech, additional, Fitts, Whitney, additional, Ni, Jing, additional, Alberta, John A., additional, Zhao, Jean, additional, Liu, Kevin X., additional, Bian, Jie, additional, Truffaux, Nathalene, additional, Weiss, William A., additional, Resnick, Adam C., additional, Bandopadhayay, Pratiti, additional, Ligon, Keith L., additional, DuBois, Steven G., additional, Mueller, Sabine, additional, Chowdhury, Dipanjan, additional, and Haas-Kogan, Daphne A., additional

Published
2018
Full Text
View/download PDF

22. Abstract 2593: Accelerating pediatric brain tumor research through team science solutions

Author

Christini, Amanda, primary, Waanders, Angela J., additional, Wagenaar, Joost B., additional, Felmeister, Alex S., additional, Santi, Mariarita, additional, Wadhwani, Nitin R., additional, Mason, Jennifer L., additional, Koptyra, Mateusz P., additional, Lilly, Jena V., additional, Pennington, Jeffrey W., additional, Lulla, Rishi R., additional, and Resnick, Adam C., additional

Published
2017
Full Text
View/download PDF

23. BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas

Author

Olow, Aleksandra, primary, Mueller, Sabine, additional, Yang, Xiaodong, additional, Hashizume, Rintaro, additional, Meyerowitz, Justin, additional, Weiss, William, additional, Resnick, Adam C., additional, Waanders, Angela J., additional, Stalpers, Lukas J.A., additional, Berger, Mitchel S., additional, Gupta, Nalin, additional, James, C. David, additional, Petritsch, Claudia K., additional, and Haas-Kogan, Daphne A., additional

Published
2016
Full Text
View/download PDF

28. Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, Gillmor, Aaron H, Kunz, Daniel J, Johnston, Michael J, Nikolic, Ana, Narta, Kiran, Zarrei, Mehdi, King, Jennifer, Ellestad, Katrina, Dang, Ngoc Ha, Cavalli, Florence MG, Kushida, Michelle M, Coutinho, Fiona J, Zhu, Yuankun, Luu, Betty, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Pugh, Trevor J, Dirks, Peter B, Strother, Douglas, Lafay-Cousin, Lucie, Resnick, Adam C, Scherer, Stephen, Senger, Donna L, Simons, Benjamin D, Chan, Jennifer A, Morrissy, A Sorana, and Gallo, Marco

Subjects
Whole Genome Sequencing, Brain Neoplasms, Gene Expression Profiling, Xenograft Model Antitumor Assays, 3. Good health, Mice, Mutation, Biomarkers, Tumor, Neoplastic Stem Cells, Tumor Cells, Cultured, Animals, Humans, Longitudinal Studies, Neoplasm Recurrence, Local, Child, Glioblastoma
Abstract

Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were collections of genetically diverse subclones. Clonal composition rapidly evolved at recurrence, with less than 8% of nonsynonymous single-nucleotide variants being shared in diagnostic-recurrent pairs. To track the origins of the mutational events observed in pGBM, we generated whole-genome datasets for two patients and their parents. These trios showed that genetic variants could be (i) somatic, (ii) inherited from a healthy parent, or (iii) de novo in the germlines of pGBM patients. Analysis of variant allele frequencies supported a model of tumor growth involving slow-cycling cancer stem cells that give rise to fast-proliferating progenitor-like cells and to nondividing cells. Interestingly, radiation and antimitotic chemotherapeutics did not increase overall tumor burden upon recurrence. These findings support an important role for slow-cycling stem cell populations in contributing to recurrences, because slow-cycling cell populations are expected to be less prone to genotoxic stress induced by these treatments and therefore would accumulate few mutations. Our results highlight the need for new targeted treatments that account for the complex functional hierarchies and genomic heterogeneity of pGBM. SIGNIFICANCE: This work challenges several assumptions regarding the genetic organization of pediatric GBM and highlights mutagenic programs that start during early prenatal development.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/79/9/2111/F1.large.jpg.

Catalog

Books, media, physical & digital resources
See catalog results