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Start Over Author "Yang, Xiaolu" Topic biochemical mechanism of action Publisher american association for the advancement of science
1 results on '"Yang, Xiaolu"'

1. Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx.

Author

Chang, Howard Y., Nishitoh, Hideki, Yang, Xiaolu, Ichijo, Hidenori, and Baltimore, David

Subjects
*PROTEINS, *APOPTOSIS, *CELL membrane formation, *ENZYMES, *PHOSPHATES, *SCIENTIFIC experimentation, *BIOCHEMICAL mechanism of action, *REACTIVITY (Chemistry)
Abstract

Finds that the Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx as found to activate the JNK kinase ASK1; Overexpression of a kinase-deficient ASK1 mutant as inhibiting Fas- and Daxx-induced apoptosis and JNK activation; Daxx-ASK1 connection as completing a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors; Conclusions.

Published
1998
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