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Your search keyword '"Bataille, Carole J. R."' showing total 1 results
Start Over Author "Bataille, Carole J. R." Publisher american association for the advancement of science
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1. A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2.

Author

Bery, Nicolas, Bataille, Carole J. R., Russell, Angela, Hayes, Angela, Raynaud, Florence, Milhas, Sabine, Anand, Sneha, Tulmin, Hanna, Miller, Ami, and Rabbitts, Terence H.

Subjects
*SMALL molecules, *SCIENTIFIC apparatus & instruments, *CHROMOSOMAL proteins, *GREEN fluorescent protein, *PROTEINS
Abstract

The article presents a study of a cell-based intracellular antibody-guided screening method to discover small molecules targeting the chromosomal translocation protein LMO2. Topics discussed include the use of a dematuration method to decrease intracellular domain antibodies (iDAb) affinity, the verification of the LMO2 antibody-derived (Abd) compounds using an in vitro orthogonal assay, and methods used in cell culture and molecular cloning.

Published
2021
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