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Start Over Author "Betty Zheng" Publisher american association for the advancement of science
1 results on '"Betty Zheng"'

1. Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.

Author

Tkachev, Victor, Furlan, Scott N., Watkins, Benjamin, Hunt, Daniel J., Hengqi Betty Zheng, Panoskaltsis-Mortari, Angela, Betz, Kayla, Brown, Melanie, Schell, John B., Zeleski, Katie, Yu, Alison, Kirby, Ian, Cooley, Sarah, Miller, Jeffrey S., Blazar, Bruce R., Casson, Duncan, Bland-Ward, Phil, and Kean, Leslie S.

Subjects
T cells, CALCINEURIN, RAPAMYCIN, IMMUNITY, TRANSPLANTATION of organs, tissues, etc., PHYSIOLOGY
Abstract

The article discusses controlling of effector T cell activation while preservation of regulatory T cell (Treg) function after transplant through combined OX40L and mTOR blockade. Topics discussed include partial control of T cell activation through calcineurin inhibitor–based strategies, more compatibility of mechanistic target of rapamycin (mTOR) inhibition with sirolimus, and combined OX40L blockade and sirolimus representing promising strategy for inducing immune balance after transplant.

Published
2017
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