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Your search keyword '"Boehning, Darren"' showing total 4 results
Start Over Author "Boehning, Darren" Publisher american association for the advancement of science
4 results on '"Boehning, Darren"'

1. Carbon monoxide and clocks. (Perspectives: circadian rhythms)

Author

Boehning, Darren and Snyder, Solomon H.

Subjects
Neurotransmitters -- Observations -- Physiological aspects, Circadian rhythms -- Physiological aspects, Carbon monoxide -- Physiological aspects, Science and technology, Observations, Physiological aspects
Abstract

The gases nitric oxide (NO) and carbon monoxide (CO) are increasingly appreciated as major neurotransmitters (1). One of the principal means by which NO and CO transmit signals between neurons [...]

Published
2002

3. Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP₃ receptor 1 promotes Ca²⁺ signaling in T cells.

Author

Fos C, Becart S, Canonigo Balancio AJ, Boehning D, and Altman A

Subjects
Animals, Blotting, Western, Cell Fractionation, DNA-Binding Proteins genetics, Genetic Vectors genetics, Guanine Nucleotide Exchange Factors, Immunoprecipitation, Interferon-gamma metabolism, Luciferases, Mice, Mice, Inbred C57BL, Mice, Knockout, Nuclear Proteins genetics, T-Lymphocytes metabolism, Calcium Signaling immunology, DNA-Binding Proteins metabolism, Inositol 1,4,5-Trisphosphate Receptors metabolism, Lymphocyte Activation immunology, Nuclear Proteins metabolism, T-Lymphocytes immunology
Abstract

The guanine nucleotide exchange factor SLAT (SWAP-70-like adaptor of T cells) regulates T cell activation and differentiation by enabling Ca(2+) release from intracellular stores in response to stimulation of the T cell receptor (TCR). We found a TCR-induced association between SLAT and inositol 1,4,5-trisphosphate (IP3) receptor type 1 (IP3R1). The N-terminal region of SLAT, which contains two EF-hand motifs that we determined bound Ca(2+), and the SLAT pleckstrin homology (PH) domain independently bound to IP3R1 by associating with a conserved motif within the IP3R1 ligand-binding domain. Disruption of the SLAT-IP3R1 interaction with cell-permeable, IP3R1-based fusion peptides inhibited TCR-stimulated Ca(2+) signaling, activation of the transcription factor NFAT (nuclear factor of activated T cells), and production of cytokines, suggesting that this interaction is required for optimal T cell activation. The finding that SLAT is an IP3R1-interacting protein required for T cell activation suggests that this interaction could be a potential target for a selective immunosuppressive drug., (Copyright © 2014, American Association for the Advancement of Science.)

Published
2014
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4. Circadian rhythms. Carbon monoxide and clocks.

Author

Boehning D and Snyder SH

Subjects
ARNTL Transcription Factors, Animals, Autonomic Nervous System metabolism, Basic Helix-Loop-Helix Transcription Factors, Behavior, Animal, Brain metabolism, CLOCK Proteins, Carbon Monoxide pharmacology, DNA metabolism, Diffusion, Dimerization, Helix-Loop-Helix Motifs, Heme metabolism, Heme Oxygenase (Decyclizing) metabolism, Mice, Models, Genetic, NAD metabolism, NADP metabolism, Neurotransmitter Agents metabolism, Oxidation-Reduction, Protein Structure, Tertiary, Synaptic Transmission, Trans-Activators metabolism, Transcription, Genetic, Carbon Monoxide metabolism, Circadian Rhythm genetics, Nerve Tissue Proteins chemistry, Nerve Tissue Proteins metabolism, Neurons metabolism, Transcription Factors chemistry, Transcription Factors metabolism
Published
2002
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