1. Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity.
- Author
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Pert A, Rosenblatt JE, Sivit C, Pert CB, and Bunney WE Jr
- Subjects
- Animals, Apomorphine pharmacology, Corpus Striatum metabolism, Haloperidol pharmacology, Humans, Male, Rats, Receptors, Dopamine metabolism, Spiperone metabolism, Stereotyped Behavior drug effects, Time Factors, Lithium pharmacology, Receptors, Dopamine drug effects
- Abstract
Long-term treatment of rats with haloperidol produced an increased sensitivity to the locomotor and stereotypic effect of apomorphine. This behavioral dopaminergic supersensitivity was accompanied by increased binding of [3H] spiroperidol in the striatum. Rats treated concurrently with lithium and haloperidol failed to develop both behavioral sensitivity to apomorphine and increased striatal dopamine receptor binding. The ability of lighium to prevent recurrent manicdepressive episodes may be related, in part, to its ability to stabilize dopaminergic receptor sensitivity.
- Published
- 1978
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