1. A Genomic view of the human-bacteroides thetaiotaomicron symbiosis. (Reports)
- Author
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Xu, Jian, Bjursell, Magnus K., Himrod, Jason, Deng, Su, Carmichael, Lynn K., Chiang, Herbert C., Hooper, Lora V., and Gordon, Jeffrey I.
- Subjects
Symbiosis -- Analysis -- Genetic aspects -- Research -- Physiological aspects ,Man -- Research -- Physiological aspects -- Genetic aspects -- Analysis ,Intestines -- Physiological aspects -- Research -- Analysis ,Human beings -- Research -- Physiological aspects -- Genetic aspects -- Analysis ,Anaerobic bacteria -- Genetic aspects -- Analysis -- Physiological aspects -- Research ,Gram-negative bacteria -- Genetic aspects -- Physiological aspects -- Analysis -- Research ,Science and technology ,Physiological aspects ,Analysis ,Research ,Genetic aspects - Abstract
The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine., A major theme of life on our planet is the complex and beneficial interactions that occur between eukaryotes and prokaryotes. Humans are no exception. As adults, we harbor diverse communities [...]
- Published
- 2003