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Start Over Author "Hanzhi Luo" Publisher american association for the advancement of science
1 results on '"Hanzhi Luo"'

1. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.

Author

Mohrin, Mary, Jiyung Shin, Yufei Liu, Brown, Katharine, Hanzhi Luo, Yannan Xi, Haynes, Cole M., and Chen, Danica

Subjects
*MITOCHONDRIAL proteins, *HEMATOPOIETIC stem cells, *CELLULAR aging, *SIRTUINS, *REGENERATION (Biology), *ENERGY metabolism, *CELL proliferation
Abstract

The article discusses how the deterioration of adult stem cells impacts compromised tissue maintenance associated with aging. Topics include the role of the nutrient-sensing, gene expression regulating Sirtuins protein family (SIRT1 to SIRT7) in mitochondrial unfolded protein response (UPR), how SIRT7 inactivation can lead to mitochondrial protein folding stress and hematopoietic stem cell regeneration issues, and the relationship between UPR and cellular energy metabolism and proliferation. [ABSTRACT FROM AUTHOR]

Published
2015
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