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Your search keyword '"Hartman, Stephen"' showing total 2 results
Start Over Author "Hartman, Stephen" Publisher american association for the advancement of science
2 results on '"Hartman, Stephen"'

1. HTRA1 promoter polymorphism in wet age-related macular degeneration

Author

DeWan, Andrew, Liu, Mugen, Hartman, Stephen, Zhang, Samuel Shao-Min, Liu, David T.L., Zhao, Connie, Tam, Pancy O.S., Chan, Wai Man, Lam, Dennis S.C., Snyder, Michael, Barnstable, Colin, Pang, Chi Pui, and Hoh, Josephine

Subjects
Morphological variation -- Research, Morphological variation -- Analysis, Macular degeneration -- Research, Macular degeneration -- Analysis
Published
2006

2. HTRA1 Promoter Polymorphism in Wet Age-Related Macular Degeneration.

Author

Andrew DeWan, Mugen Liu, Hartman, Stephen, Samuel Shao-Min Zhang, Liu, David T. L., Connie Zhao, Tam, Pancy O. S., Wai Man Chan, Lam, Dennis S. C., Snyder, Michael, Barnstable, Colin, Chi Pui Pang, and Josephine Hoh

Subjects
*GENETIC polymorphisms, *RETINAL degeneration, *GENETICS, *DISEASES in older people, *PROTEOLYTIC enzymes, *GENES, *CHROMOSOMES, *NUCLEOTIDES, *POPULATION genetics
Abstract

Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular). Inherited variation in the complement factor H gene is a major risk factor for drusen in dry AMD. Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD. A whole-genome association mapping strategy was applied to a Chinese population, yielding a P value of <10-11. Individuals with the risk-associated genotype were estimated to have a likelihood of developing wet AMD 10 times that of individuals with the wild-type genotype. [ABSTRACT FROM AUTHOR]

Published
2006
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